HJURP protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

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Cooccurrence

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[Homology]

Score

HJURP

Holliday junction recognition protein. (752 aa)

Predicted Functional Partners:

CENPA

0.997

MIS18BP1

0.969

SPAG5

0.955

CDCA8

0.947

ASPM

0.946

KIF20A

0.945

CENPF

0.940

TOP2A

0.938

KIF11

0.914

TROAP

0.912

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPM	CDCA8	ENSCAFP00000016776	ENSCAFP00000004866	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Cell division cycle associated 8.	0.909
ASPM	CENPA	ENSCAFP00000016776	ENSCAFP00000006652	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Centromere protein A.	0.732
ASPM	CENPF	ENSCAFP00000016776	ENSCAFP00000018561	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Centromere protein F.	0.977
ASPM	HJURP	ENSCAFP00000016776	ENSCAFP00000036068	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Holliday junction recognition protein.	0.946
ASPM	KIF11	ENSCAFP00000016776	ENSCAFP00000011137	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.966
ASPM	KIF20A	ENSCAFP00000016776	ENSCAFP00000001720	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.960
ASPM	MIS18BP1	ENSCAFP00000016776	ENSCAFP00000020774	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	MIS18 binding protein 1.	0.821
ASPM	SPAG5	ENSCAFP00000016776	ENSCAFP00000027622	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Sperm associated antigen 5.	0.955
ASPM	TOP2A	ENSCAFP00000016776	ENSCAFP00000042966	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.966
ASPM	TROAP	ENSCAFP00000016776	ENSCAFP00000012633	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Trophinin associated protein.	0.769
CDCA8	ASPM	ENSCAFP00000004866	ENSCAFP00000016776	Cell division cycle associated 8.	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	0.909
CDCA8	CENPA	ENSCAFP00000004866	ENSCAFP00000006652	Cell division cycle associated 8.	Centromere protein A.	0.922
CDCA8	CENPF	ENSCAFP00000004866	ENSCAFP00000018561	Cell division cycle associated 8.	Centromere protein F.	0.933
CDCA8	HJURP	ENSCAFP00000004866	ENSCAFP00000036068	Cell division cycle associated 8.	Holliday junction recognition protein.	0.947
CDCA8	KIF11	ENSCAFP00000004866	ENSCAFP00000011137	Cell division cycle associated 8.	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.937
CDCA8	KIF20A	ENSCAFP00000004866	ENSCAFP00000001720	Cell division cycle associated 8.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.959
CDCA8	MIS18BP1	ENSCAFP00000004866	ENSCAFP00000020774	Cell division cycle associated 8.	MIS18 binding protein 1.	0.691
CDCA8	SPAG5	ENSCAFP00000004866	ENSCAFP00000027622	Cell division cycle associated 8.	Sperm associated antigen 5.	0.924
CDCA8	TOP2A	ENSCAFP00000004866	ENSCAFP00000042966	Cell division cycle associated 8.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.925
CDCA8	TROAP	ENSCAFP00000004866	ENSCAFP00000012633	Cell division cycle associated 8.	Trophinin associated protein.	0.851

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Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.888

expected number of edges:

11

PPI enrichment p-value:

1.06e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032511

Late endosome to vacuole transport via multivesicular body sorting pathway

3 of 13

2.54

1.61

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30572

Mixed, incl. Late endosome to vacuole transport via multivesicular body sorting pathway, and HCN channels

9 of 30

2.66

9.23

1.61e-19

CL:30574

Mixed, incl. Late endosome to vacuole transport via multivesicular body sorting pathway, and Polypeptide N-acetylgalactosaminyltransferase activity

8 of 18

2.83

9.07

2.19e-18

CL:30577

Mixed, incl. Synaptonemal complex protein 2-like, and Rab-GTPase-TBC domain

5 of 6

3.1

5.88

1.49e-11

CL:30595

Vps55/LEPROT, and Uncharacterised protein family UPF0220

3 of 5

2.96

2.81

7.42e-06

CL:19564

Dystrophin-associated glycoprotein complex, and EF-hand

2 of 14

2.33

0.87

0.0251

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016012

Sarcoglycan complex

2 of 5

2.78

1.04

0.0129

GOCC:0005927

Muscle tendon junction

2 of 6

2.7

1.04

0.0129

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05255

Uncharacterised protein family (UPF0220)

2 of 2

3.18

1.3

0.0046

PF04790

Sarcoglycan complex subunit protein

2 of 5

2.78

1.15

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007919

Uncharacterised protein family UPF0220

2 of 2

3.18

1.02

0.0145

IPR039972

Sarcoglycan gamma/delta/zeta

2 of 4

2.88

0.97

0.0181

IPR006875

Sarcoglycan complex subunit protein

2 of 5

2.78

0.96

0.0181

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