STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FXNFrataxin. (211 aa)    
Predicted Functional Partners:
NFS1
Aminotran_5 domain-containing protein.
   
 0.999
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
   
 0.991
ISCU
Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.
   
 0.985
SCLY
Selenocysteine lyase.
   
 0.971
HMOX2
Heme oxygenase 2.
   
 
 0.931
HMOX1
Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.
   
 
 0.930
ENSCAFP00000056596
NifU_N domain-containing protein.
    
 
 0.930
HEPH
Hephaestin; Belongs to the multicopper oxidase family.
     
 0.918
LOC611632
Uncharacterized protein; Belongs to the multicopper oxidase family.
     
 0.918
CP
Ceruloplasmin; Belongs to the multicopper oxidase family.
     
 0.918
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.