STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCNH5Potassium voltage-gated channel subfamily H member 5. (988 aa)    
Predicted Functional Partners:
PRKCH
Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...]
   
  
 0.791
TANC1
Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1.
   
  
 0.789
GPATCH1
G-patch domain containing 1.
      
 0.788
ASCL4
Achaete-scute family bHLH transcription factor 4.
      
 0.783
BAZ2B
Bromodomain adjacent to zinc finger domain 2B.
      
 0.783
KCNAB1
Potassium voltage-gated channel subfamily A member regulatory beta subunit 1.
    
 0.677
KCNAB2
Potassium voltage-gated channel subfamily A regulatory beta subunit 2.
    
 0.677
KCNQ2
Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family.
   
 
 0.672
KCNAB3
Potassium voltage-gated channel subfamily A regulatory beta subunit 3.
   
 0.635
CASK
Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.
   
 
 0.582
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.