node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF6 | CNGA3 | ENSCAFP00000058006 | ENSCAFP00000066106 | Activating transcription factor 6. | Cyclic nucleotide-gated channel alpha 3. | 0.693 |
ATF6 | CNGB3 | ENSCAFP00000058006 | ENSCAFP00000013075 | Activating transcription factor 6. | Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...] | 0.818 |
ATF6 | GNAT2 | ENSCAFP00000058006 | ENSCAFP00000029355 | Activating transcription factor 6. | G protein subunit alpha transducin 2. | 0.698 |
ATF6 | PDE6C | ENSCAFP00000058006 | ENSCAFP00000011712 | Activating transcription factor 6. | Phosphodiesterase. | 0.664 |
ATF6 | PDE6H | ENSCAFP00000058006 | ENSCAFP00000057342 | Activating transcription factor 6. | Phosphodiesterase 6H. | 0.725 |
CNGA1 | CNGB3 | ENSCAFP00000035274 | ENSCAFP00000013075 | cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. | Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...] | 0.919 |
CNGA1 | GNAT2 | ENSCAFP00000035274 | ENSCAFP00000029355 | cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. | G protein subunit alpha transducin 2. | 0.503 |
CNGA1 | PDE6B | ENSCAFP00000035274 | ENSCAFP00000024683 | cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.703 |
CNGA1 | PDE6C | ENSCAFP00000035274 | ENSCAFP00000011712 | cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. | Phosphodiesterase. | 0.594 |
CNGA1 | PDE6H | ENSCAFP00000035274 | ENSCAFP00000057342 | cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. | Phosphodiesterase 6H. | 0.717 |
CNGA1 | RGS9BP | ENSCAFP00000035274 | ENSCAFP00000011151 | cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. | Regulator of G protein signaling 9 binding protein. | 0.562 |
CNGA1 | RPE65 | ENSCAFP00000035274 | ENSCAFP00000030301 | cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. | Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-tra [...] | 0.481 |
CNGA3 | ATF6 | ENSCAFP00000066106 | ENSCAFP00000058006 | Cyclic nucleotide-gated channel alpha 3. | Activating transcription factor 6. | 0.693 |
CNGA3 | CNGB3 | ENSCAFP00000066106 | ENSCAFP00000013075 | Cyclic nucleotide-gated channel alpha 3. | Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...] | 0.933 |
CNGA3 | GNAT2 | ENSCAFP00000066106 | ENSCAFP00000029355 | Cyclic nucleotide-gated channel alpha 3. | G protein subunit alpha transducin 2. | 0.922 |
CNGA3 | HHATL | ENSCAFP00000066106 | ENSCAFP00000007992 | Cyclic nucleotide-gated channel alpha 3. | Hedgehog acyltransferase like. | 0.548 |
CNGA3 | PDE6B | ENSCAFP00000066106 | ENSCAFP00000024683 | Cyclic nucleotide-gated channel alpha 3. | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.565 |
CNGA3 | PDE6C | ENSCAFP00000066106 | ENSCAFP00000011712 | Cyclic nucleotide-gated channel alpha 3. | Phosphodiesterase. | 0.923 |
CNGA3 | PDE6H | ENSCAFP00000066106 | ENSCAFP00000057342 | Cyclic nucleotide-gated channel alpha 3. | Phosphodiesterase 6H. | 0.883 |
CNGA3 | RPE65 | ENSCAFP00000066106 | ENSCAFP00000030301 | Cyclic nucleotide-gated channel alpha 3. | Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-tra [...] | 0.711 |