STUB1 protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

gene neighborhood

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[Homology]

Score

STUB1

STIP1 homology and U-box containing protein 1. (306 aa)

Predicted Functional Partners:

UBE2D1

0.961

HSPA4

0.961

SMAD3

0.923

BAG3

0.917

TP53

0.817

ERBB2

0.816

UBE2D3

0.805

SLC39A13

0.801

MAPT

0.796

RIPK3

0.745

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAG3	HSPA4	ENSCAFP00000017970	ENSCAFP00000062263	BCL2 associated athanogene 3.	Heat shock 70 kDa protein 4.	0.785
BAG3	STUB1	ENSCAFP00000017970	ENSCAFP00000036229	BCL2 associated athanogene 3.	STIP1 homology and U-box containing protein 1.	0.917
BAG3	TP53	ENSCAFP00000017970	ENSCAFP00000064590	BCL2 associated athanogene 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.448
ERBB2	HSPA4	ENSCAFP00000024079	ENSCAFP00000062263	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Heat shock 70 kDa protein 4.	0.533
ERBB2	STUB1	ENSCAFP00000024079	ENSCAFP00000036229	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	STIP1 homology and U-box containing protein 1.	0.816
ERBB2	TP53	ENSCAFP00000024079	ENSCAFP00000064590	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.726
HSPA4	BAG3	ENSCAFP00000062263	ENSCAFP00000017970	Heat shock 70 kDa protein 4.	BCL2 associated athanogene 3.	0.785
HSPA4	ERBB2	ENSCAFP00000062263	ENSCAFP00000024079	Heat shock 70 kDa protein 4.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.533
HSPA4	MAPT	ENSCAFP00000062263	ENSCAFP00000046670	Heat shock 70 kDa protein 4.	Microtubule-associated protein.	0.740
HSPA4	STUB1	ENSCAFP00000062263	ENSCAFP00000036229	Heat shock 70 kDa protein 4.	STIP1 homology and U-box containing protein 1.	0.961
HSPA4	TP53	ENSCAFP00000062263	ENSCAFP00000064590	Heat shock 70 kDa protein 4.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.821
MAPT	HSPA4	ENSCAFP00000046670	ENSCAFP00000062263	Microtubule-associated protein.	Heat shock 70 kDa protein 4.	0.740
MAPT	STUB1	ENSCAFP00000046670	ENSCAFP00000036229	Microtubule-associated protein.	STIP1 homology and U-box containing protein 1.	0.796
RIPK3	STUB1	ENSCAFP00000047856	ENSCAFP00000036229	Protein kinase domain-containing protein.	STIP1 homology and U-box containing protein 1.	0.745
SLC39A13	STUB1	ENSCAFP00000012813	ENSCAFP00000036229	Solute carrier family 39 member 13.	STIP1 homology and U-box containing protein 1.	0.801
SMAD3	STUB1	ENSCAFP00000025647	ENSCAFP00000036229	Mothers against decapentaplegic homolog.	STIP1 homology and U-box containing protein 1.	0.923
SMAD3	TP53	ENSCAFP00000025647	ENSCAFP00000064590	Mothers against decapentaplegic homolog.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.782
SMAD3	UBE2D1	ENSCAFP00000025647	ENSCAFP00000036387	Mothers against decapentaplegic homolog.	Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family.	0.439
SMAD3	UBE2D3	ENSCAFP00000025647	ENSCAFP00000043478	Mothers against decapentaplegic homolog.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.439
STUB1	BAG3	ENSCAFP00000036229	ENSCAFP00000017970	STIP1 homology and U-box containing protein 1.	BCL2 associated athanogene 3.	0.917