DROSHA protein (Canis lupus familiaris) - STRING interaction network

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gene neighborhood

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Score

DROSHA

Drosha ribonuclease III. (1398 aa)

Predicted Functional Partners:

DGCR8

0.999

XPO5

0.940

AGO2

0.891

AGO1

0.845

MRPS9

0.827

MRPL27

0.818

MRPL19

0.811

MRPS6

0.806

MRPL17

0.804

MRPL46

0.792

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSCAFP00000005209	ENSCAFP00000043303	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.924
AGO1	DGCR8	ENSCAFP00000005209	ENSCAFP00000020922	Argonaute RISC component 1; Belongs to the argonaute family.	DGCR8 microprocessor complex subunit.	0.458
AGO1	DROSHA	ENSCAFP00000005209	ENSCAFP00000036251	Argonaute RISC component 1; Belongs to the argonaute family.	Drosha ribonuclease III.	0.845
AGO1	XPO5	ENSCAFP00000005209	ENSCAFP00000042202	Argonaute RISC component 1; Belongs to the argonaute family.	Exportin 5.	0.685
AGO2	AGO1	ENSCAFP00000043303	ENSCAFP00000005209	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC component 1; Belongs to the argonaute family.	0.924
AGO2	DGCR8	ENSCAFP00000043303	ENSCAFP00000020922	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DGCR8 microprocessor complex subunit.	0.731
AGO2	DROSHA	ENSCAFP00000043303	ENSCAFP00000036251	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Drosha ribonuclease III.	0.891
AGO2	XPO5	ENSCAFP00000043303	ENSCAFP00000042202	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Exportin 5.	0.906
DGCR8	AGO1	ENSCAFP00000020922	ENSCAFP00000005209	DGCR8 microprocessor complex subunit.	Argonaute RISC component 1; Belongs to the argonaute family.	0.458
DGCR8	AGO2	ENSCAFP00000020922	ENSCAFP00000043303	DGCR8 microprocessor complex subunit.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.731
DGCR8	DROSHA	ENSCAFP00000020922	ENSCAFP00000036251	DGCR8 microprocessor complex subunit.	Drosha ribonuclease III.	0.999
DGCR8	XPO5	ENSCAFP00000020922	ENSCAFP00000042202	DGCR8 microprocessor complex subunit.	Exportin 5.	0.925
DROSHA	AGO1	ENSCAFP00000036251	ENSCAFP00000005209	Drosha ribonuclease III.	Argonaute RISC component 1; Belongs to the argonaute family.	0.845
DROSHA	AGO2	ENSCAFP00000036251	ENSCAFP00000043303	Drosha ribonuclease III.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.891
DROSHA	DGCR8	ENSCAFP00000036251	ENSCAFP00000020922	Drosha ribonuclease III.	DGCR8 microprocessor complex subunit.	0.999
DROSHA	MRPL17	ENSCAFP00000036251	ENSCAFP00000009852	Drosha ribonuclease III.	Mitochondrial ribosomal protein L17; Belongs to the bacterial ribosomal protein bL17 family.	0.804
DROSHA	MRPL19	ENSCAFP00000036251	ENSCAFP00000012030	Drosha ribonuclease III.	Mitochondrial ribosomal protein L19.	0.811
DROSHA	MRPL27	ENSCAFP00000036251	ENSCAFP00000025072	Drosha ribonuclease III.	Mitochondrial ribosomal protein L27.	0.818
DROSHA	MRPL46	ENSCAFP00000036251	ENSCAFP00000016887	Drosha ribonuclease III.	Mitochondrial ribosomal protein L46.	0.792
DROSHA	MRPS6	ENSCAFP00000036251	ENSCAFP00000044700	Drosha ribonuclease III.	Mitochondrial ribosomal protein S6.	0.806