STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)    
Predicted Functional Partners:
FOSL2
FOS like 2, AP-1 transcription factor subunit.
   
 0.985
FOS
Fos proto-oncogene, AP-1 transcription factor subunit.
   
 0.974
FOSL1
FOS like 1, AP-1 transcription factor subunit.
   
 0.972
MAPK8
Mitogen-activated protein kinase.
   
 0.967
JUND
JunD proto-oncogene, AP-1 transcription factor subunit.
   
0.965
MAPK10
Mitogen-activated protein kinase.
    
 0.963
MAPK9
Mitogen-activated protein kinase.
    
 0.963
JDP2
Jun dimerization protein 2.
   
 
 0.879
FOSB
Protein fosB; FosB interacts with Jun proteins enhancing their DNA binding activity.
   
 
 0.799
MAPK14
Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...]
   
 0.719
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.