STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF145Ring finger protein 145. (677 aa)    
Predicted Functional Partners:
INSIG2
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
   
 
 0.784
NPEPL1
Aminopeptidase like 1.
      
 0.769
UBIAD1
UbiA prenyltransferase domain containing 1.
      
 0.709
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.708
INSIG1
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
    
 
 0.707
RNF150
Ring finger protein 150.
    
 
 0.684
SEL1L
SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.
   
 
 0.636
VCP
Valosin containing protein; Belongs to the AAA ATPase family.
   
 
 0.634
MRPL19
Mitochondrial ribosomal protein L19.
 
      0.628
MARCHF6
Membrane associated ring-CH-type finger 6.
    
 
 0.627
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.