STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IGF2RCation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor protein. (2497 aa)    
Predicted Functional Partners:
IGF2
Insulin like growth factor 2.
   
 
 0.999
IGF1
Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]
      
 0.965
M6PR
Mannose-6-phosphate receptor, cation dependent.
   
 
 0.962
GGA3
Golgi associated, gamma adaptin ear containing, ARF binding protein 3.
    
 
 0.942
GGA1
Golgi associated, gamma adaptin ear containing, ARF binding protein 1.
   
 
 0.934
IGF1R
Tyrosine-protein kinase receptor.
   
 
 0.906
GGA2
Golgi associated, gamma adaptin ear containing, ARF binding protein 2.
   
 
 0.804
SORT1
Sortilin.
   
 0.754
SNX2
Sorting nexin 2.
    
 0.752
PLIN3
Perilipin; Belongs to the perilipin family.
   
 0.742
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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