RPS6KB2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	DEPTOR	ENSCAFP00000005180	ENSCAFP00000001263	AKT1 substrate 1.	DEP domain containing MTOR interacting protein.	0.985
AKT1S1	MLST8	ENSCAFP00000005180	ENSCAFP00000030885	AKT1 substrate 1.	MTOR associated protein, LST8 homolog.	0.988
AKT1S1	MTOR	ENSCAFP00000005180	ENSCAFP00000024527	AKT1 substrate 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.993
AKT1S1	PRKACA	ENSCAFP00000005180	ENSCAFP00000053880	AKT1 substrate 1.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.818
AKT1S1	PRKACB	ENSCAFP00000005180	ENSCAFP00000030135	AKT1 substrate 1.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.887
AKT1S1	RPS6KB2	ENSCAFP00000005180	ENSCAFP00000036722	AKT1 substrate 1.	Non-specific serine/threonine protein kinase.	0.949
AKT1S1	RPTOR	ENSCAFP00000005180	ENSCAFP00000008518	AKT1 substrate 1.	Regulatory associated protein of MTOR complex 1.	0.997
DEPTOR	AKT1S1	ENSCAFP00000001263	ENSCAFP00000005180	DEP domain containing MTOR interacting protein.	AKT1 substrate 1.	0.985
DEPTOR	MLST8	ENSCAFP00000001263	ENSCAFP00000030885	DEP domain containing MTOR interacting protein.	MTOR associated protein, LST8 homolog.	0.997
DEPTOR	MTOR	ENSCAFP00000001263	ENSCAFP00000024527	DEP domain containing MTOR interacting protein.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.991
DEPTOR	RPS6KB2	ENSCAFP00000001263	ENSCAFP00000036722	DEP domain containing MTOR interacting protein.	Non-specific serine/threonine protein kinase.	0.938
DEPTOR	RPTOR	ENSCAFP00000001263	ENSCAFP00000008518	DEP domain containing MTOR interacting protein.	Regulatory associated protein of MTOR complex 1.	0.992
ESR1	MTOR	ENSCAFP00000000624	ENSCAFP00000024527	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.703
ESR1	PRKACA	ENSCAFP00000000624	ENSCAFP00000053880	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.934
ESR1	PRKACB	ENSCAFP00000000624	ENSCAFP00000030135	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.933
ESR1	RPS6KB2	ENSCAFP00000000624	ENSCAFP00000036722	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Non-specific serine/threonine protein kinase.	0.906
IRS2	MTOR	ENSCAFP00000009098	ENSCAFP00000024527	Insulin receptor substrate 2.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.962
IRS2	RPS6KB2	ENSCAFP00000009098	ENSCAFP00000036722	Insulin receptor substrate 2.	Non-specific serine/threonine protein kinase.	0.929
IRS2	RPTOR	ENSCAFP00000009098	ENSCAFP00000008518	Insulin receptor substrate 2.	Regulatory associated protein of MTOR complex 1.	0.545
MLST8	AKT1S1	ENSCAFP00000030885	ENSCAFP00000005180	MTOR associated protein, LST8 homolog.	AKT1 substrate 1.	0.988