STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DTHD1Death domain containing 1. (904 aa)    
Predicted Functional Partners:
CLUAP1
Clusterin associated protein 1.
      
 0.802
CCT2
Chaperonin containing TCP1 subunit 2.
      
 0.679
KCNJ13
Potassium voltage-gated channel subfamily J member 13.
      
 0.674
AIPL1
Aryl hydrocarbon receptor interacting protein like 1.
      
 0.648
IFT140
Uncharacterized protein.
      
 0.647
IQCB1
IQ motif containing B1.
      
 0.607
RD3
Uncharacterized protein.
      
 0.598
CABP4
Calcium binding protein 4.
      
 0.593
CRX
Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors (By similarity); Belongs to the paired homeobox family.
      
 0.591
GDF6
Growth differentiation factor 6.
      
 0.574
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.