| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP4A | CCKBR | ENSCAFP00000055733 | ENSCAFP00000009585 | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. | 0.587 |
| ATP4A | GAST | ENSCAFP00000055733 | ENSCAFP00000023420 | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine; Belongs to the gastrin/cholecystokinin family. | 0.852 |
| ATP4A | HRH2 | ENSCAFP00000055733 | ENSCAFP00000053813 | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. | Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | 0.824 |
| CCKBR | ATP4A | ENSCAFP00000009585 | ENSCAFP00000055733 | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. | 0.587 |
| CCKBR | GAST | ENSCAFP00000009585 | ENSCAFP00000023420 | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine; Belongs to the gastrin/cholecystokinin family. | 0.998 |
| CCKBR | HDC | ENSCAFP00000009585 | ENSCAFP00000022221 | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. | Histidine decarboxylase. | 0.552 |
| CCKBR | HRH2 | ENSCAFP00000009585 | ENSCAFP00000053813 | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. | Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | 0.567 |
| CREB1 | HRH2 | ENSCAFP00000019912 | ENSCAFP00000053813 | cAMP responsive element binding protein 1. | Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | 0.523 |
| GAST | ATP4A | ENSCAFP00000023420 | ENSCAFP00000055733 | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine; Belongs to the gastrin/cholecystokinin family. | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. | 0.852 |
| GAST | CCKBR | ENSCAFP00000023420 | ENSCAFP00000009585 | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine; Belongs to the gastrin/cholecystokinin family. | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. | 0.998 |
| GAST | HDC | ENSCAFP00000023420 | ENSCAFP00000022221 | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine; Belongs to the gastrin/cholecystokinin family. | Histidine decarboxylase. | 0.574 |
| GAST | HRH2 | ENSCAFP00000023420 | ENSCAFP00000053813 | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine; Belongs to the gastrin/cholecystokinin family. | Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | 0.825 |
| GNAL | HRH2 | ENSCAFP00000053739 | ENSCAFP00000053813 | G protein subunit alpha L. | Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | 0.942 |
| HDC | CCKBR | ENSCAFP00000022221 | ENSCAFP00000009585 | Histidine decarboxylase. | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. | 0.552 |
| HDC | GAST | ENSCAFP00000022221 | ENSCAFP00000023420 | Histidine decarboxylase. | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine; Belongs to the gastrin/cholecystokinin family. | 0.574 |
| HDC | HNMT | ENSCAFP00000022221 | ENSCAFP00000007736 | Histidine decarboxylase. | Histamine N-methyltransferase. | 0.972 |
| HDC | HRH2 | ENSCAFP00000022221 | ENSCAFP00000053813 | Histidine decarboxylase. | Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | 0.752 |
| HNMT | HDC | ENSCAFP00000007736 | ENSCAFP00000022221 | Histamine N-methyltransferase. | Histidine decarboxylase. | 0.972 |
| HNMT | HRH2 | ENSCAFP00000007736 | ENSCAFP00000053813 | Histamine N-methyltransferase. | Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | 0.511 |
| HRH2 | ATP4A | ENSCAFP00000053813 | ENSCAFP00000055733 | Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. | 0.824 |