J9NWU7_CANLF protein (Canis lupus familiaris)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Score

J9NWU7_CANLF

UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (128 aa)

Predicted Functional Partners:

UBE2V2

0.854

TRIP12

0.781

UBE2V1

0.755

ENSCAFP00000053186

0.755

ENSCAFP00000047437

0.710

RNF8

0.702

TRAF6

0.694

UBB

0.668

LOC100685053

0.668

RPS27A

0.633

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAFP00000047437	ENSCAFP00000053186	ENSCAFP00000047437	ENSCAFP00000053186	Uncharacterized protein.	annotation not available	0.611
ENSCAFP00000047437	J9NWU7_CANLF	ENSCAFP00000047437	ENSCAFP00000037758	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.710
ENSCAFP00000047437	LOC100685053	ENSCAFP00000047437	ENSCAFP00000066632	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.750
ENSCAFP00000047437	RNF8	ENSCAFP00000047437	ENSCAFP00000053376	Uncharacterized protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.663
ENSCAFP00000047437	RPS27A	ENSCAFP00000047437	ENSCAFP00000031429	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.982
ENSCAFP00000047437	TRAF6	ENSCAFP00000047437	ENSCAFP00000010159	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.414
ENSCAFP00000047437	UBB	ENSCAFP00000047437	ENSCAFP00000063279	Uncharacterized protein.	Ubiquitin B.	0.750
ENSCAFP00000047437	UBE2V1	ENSCAFP00000047437	ENSCAFP00000041429	Uncharacterized protein.	Ubiquitin conjugating enzyme E2 V1.	0.611
ENSCAFP00000053186	ENSCAFP00000047437	ENSCAFP00000053186	ENSCAFP00000047437	annotation not available	Uncharacterized protein.	0.611
ENSCAFP00000053186	J9NWU7_CANLF	ENSCAFP00000053186	ENSCAFP00000037758	annotation not available	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.755
ENSCAFP00000053186	LOC100685053	ENSCAFP00000053186	ENSCAFP00000066632	annotation not available	Ubiquitin-like domain-containing protein.	0.737
ENSCAFP00000053186	RNF8	ENSCAFP00000053186	ENSCAFP00000053376	annotation not available	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.668
ENSCAFP00000053186	RPS27A	ENSCAFP00000053186	ENSCAFP00000031429	annotation not available	Ubiquitin-like domain-containing protein.	0.981
ENSCAFP00000053186	UBB	ENSCAFP00000053186	ENSCAFP00000063279	annotation not available	Ubiquitin B.	0.737
ENSCAFP00000053186	UBE2V1	ENSCAFP00000053186	ENSCAFP00000041429	annotation not available	Ubiquitin conjugating enzyme E2 V1.	0.614
J9NWU7_CANLF	ENSCAFP00000047437	ENSCAFP00000037758	ENSCAFP00000047437	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.710
J9NWU7_CANLF	ENSCAFP00000053186	ENSCAFP00000037758	ENSCAFP00000053186	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	annotation not available	0.755
J9NWU7_CANLF	LOC100685053	ENSCAFP00000037758	ENSCAFP00000066632	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.668
J9NWU7_CANLF	RNF8	ENSCAFP00000037758	ENSCAFP00000053376	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.702
J9NWU7_CANLF	RPS27A	ENSCAFP00000037758	ENSCAFP00000031429	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.633

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Network Stats

number of nodes:

10

number of edges:

38

average node degree:

7.6

avg. local clustering coefficient:

0.903

expected number of edges:

10

PPI enrichment p-value:

2.79e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031463

Cul3-RING ubiquitin ligase complex

4 of 40

2.26

2.57

9.83e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37495603

(2023) A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.

3 of 26

2.33

0.87

0.0251

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:27170

Mostly uncharacterized, incl. Cerebellum maturation, and Telomeric loop formation

3 of 18

2.49

1.7

0.00072

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-8951664

Neddylation

5 of 214

1.63

1.71

0.00010

CFA-983168

Antigen processing: Ubiquitination & Proteasome degradation

4 of 280

1.42

0.95

0.0067

CFA-597592

Post-translational protein modification

6 of 1073

1.01

0.72

0.0067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031463

Cul3-RING ubiquitin ligase complex

3 of 31

2.25

1.53

0.0013

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0880

Kelch repeat

3 of 48

2.06

1.54

0.0010

KW-0677

Repeat

5 of 1186

0.89

0.47

0.0497

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00875

BTB And C-terminal Kelch

3 of 56

1.99

1.29

0.0031

SM00225

Broad-Complex, Tramtrack and Bric a brac

3 of 158

1.54

0.73

0.0316

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