STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C1QTNF12C1q and TNF related 12. (425 aa)    
Predicted Functional Partners:
MARCHF6
Membrane associated ring-CH-type finger 6.
    
 
 0.680
SAMD4B
Sterile alpha motif domain containing 4B.
      
 0.677
UBE2G2
Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.484
KLF15
Kruppel like factor 15.
      
 0.483
CAPN7
Calpain 7; Belongs to the peptidase C2 family.
      
 0.450
DYRK4
Dual specificity tyrosine phosphorylation regulated kinase 4.
      
 0.450
DSPP
Uncharacterized protein.
    
 
 0.441
ATG7
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]
   
 
 0.437
TRIP12
Thyroid hormone receptor interactor 12.
      
 0.418
KLF3
Kruppel like factor 3.
      
 0.407
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.