STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PKDCCProtein kinase domain containing, cytoplasmic. (506 aa)    
Predicted Functional Partners:
KCNG3
Potassium voltage-gated channel modifier subfamily G member 3; Belongs to the potassium channel family.
   
 
 0.761
PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
   
  
 0.677
CYB561
Cytochrome b561.
      
 0.666
FREM1
FRAS1 related extracellular matrix 1.
      
 0.637
LRRC32
Leucine rich repeat containing 32.
    
 
 0.636
STAC2
SH3 and cysteine rich domain 2.
   
 
 0.590
VIT
Vitrin.
   
 
 0.586
TSC22D2
TSC22 domain family member 2.
    
 
 0.575
RRP36
Ribosomal RNA processing 36.
   
  
 0.549
THSD4
Thrombospondin type 1 domain containing 4.
    
 
 0.519
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (20%) [HD]