MMP1 protein (Canis lupus familiaris) - STRING interaction network

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Score

MMP1

Matrix metallopeptidase 1. (465 aa)

Predicted Functional Partners:

TIMP1

0.953

MMP9

0.952

MMP3

0.950

MMP2

0.946

TIMP2

0.814

MMP13

0.698

MMP7

0.675

TIMP3

0.668

IL1B

0.666

MMP11

0.655

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL1B	MMP1	ENSCAFP00000010762	ENSCAFP00000038708	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Matrix metallopeptidase 1.	0.666
IL1B	MMP13	ENSCAFP00000010762	ENSCAFP00000022174	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Matrix metallopeptidase 13.	0.809
IL1B	MMP2	ENSCAFP00000010762	ENSCAFP00000013872	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Matrix metallopeptidase 2.	0.516
IL1B	MMP3	ENSCAFP00000010762	ENSCAFP00000022195	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family.	0.782
IL1B	MMP7	ENSCAFP00000010762	ENSCAFP00000030464	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Matrix metallopeptidase 7.	0.480
IL1B	MMP9	ENSCAFP00000010762	ENSCAFP00000035167	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.907
IL1B	TIMP1	ENSCAFP00000010762	ENSCAFP00000062428	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Metalloproteinase inhibitor 1.	0.669
IL1B	TIMP2	ENSCAFP00000010762	ENSCAFP00000035219	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.554
IL1B	TIMP3	ENSCAFP00000010762	ENSCAFP00000040576	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	TIMP metallopeptidase inhibitor 3.	0.445
MMP1	IL1B	ENSCAFP00000038708	ENSCAFP00000010762	Matrix metallopeptidase 1.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.666
MMP1	MMP11	ENSCAFP00000038708	ENSCAFP00000055831	Matrix metallopeptidase 1.	Matrix metallopeptidase 11.	0.655
MMP1	MMP13	ENSCAFP00000038708	ENSCAFP00000022174	Matrix metallopeptidase 1.	Matrix metallopeptidase 13.	0.698
MMP1	MMP2	ENSCAFP00000038708	ENSCAFP00000013872	Matrix metallopeptidase 1.	Matrix metallopeptidase 2.	0.946
MMP1	MMP3	ENSCAFP00000038708	ENSCAFP00000022195	Matrix metallopeptidase 1.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family.	0.950
MMP1	MMP7	ENSCAFP00000038708	ENSCAFP00000030464	Matrix metallopeptidase 1.	Matrix metallopeptidase 7.	0.675
MMP1	MMP9	ENSCAFP00000038708	ENSCAFP00000035167	Matrix metallopeptidase 1.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.952
MMP1	TIMP1	ENSCAFP00000038708	ENSCAFP00000062428	Matrix metallopeptidase 1.	Metalloproteinase inhibitor 1.	0.953
MMP1	TIMP2	ENSCAFP00000038708	ENSCAFP00000035219	Matrix metallopeptidase 1.	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.814
MMP1	TIMP3	ENSCAFP00000038708	ENSCAFP00000040576	Matrix metallopeptidase 1.	TIMP metallopeptidase inhibitor 3.	0.668
MMP11	MMP1	ENSCAFP00000055831	ENSCAFP00000038708	Matrix metallopeptidase 11.	Matrix metallopeptidase 1.	0.655