node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CER1 | WNT6 | ENSCAFP00000002216 | ENSCAFP00000038712 | Cerberus 1, DAN family BMP antagonist. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.901 |
FZD1 | LRP5 | ENSCAFP00000002804 | ENSCAFP00000016050 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.974 |
FZD1 | WIF1 | ENSCAFP00000002804 | ENSCAFP00000061273 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | WNT inhibitory factor 1. | 0.473 |
FZD1 | WNT6 | ENSCAFP00000002804 | ENSCAFP00000038712 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.865 |
FZD10 | LRP5 | ENSCAFP00000010143 | ENSCAFP00000016050 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.922 |
FZD10 | WIF1 | ENSCAFP00000010143 | ENSCAFP00000061273 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | WNT inhibitory factor 1. | 0.627 |
FZD10 | WNT6 | ENSCAFP00000010143 | ENSCAFP00000038712 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.867 |
FZD3 | FZD4 | ENSCAFP00000012176 | ENSCAFP00000053452 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.646 |
FZD3 | FZD6 | ENSCAFP00000012176 | ENSCAFP00000000924 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.577 |
FZD3 | LRP5 | ENSCAFP00000012176 | ENSCAFP00000016050 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.950 |
FZD3 | WNT6 | ENSCAFP00000012176 | ENSCAFP00000038712 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.959 |
FZD4 | FZD3 | ENSCAFP00000053452 | ENSCAFP00000012176 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.646 |
FZD4 | FZD6 | ENSCAFP00000053452 | ENSCAFP00000000924 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.607 |
FZD4 | LRP5 | ENSCAFP00000053452 | ENSCAFP00000016050 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.988 |
FZD4 | WNT6 | ENSCAFP00000053452 | ENSCAFP00000038712 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.949 |
FZD6 | FZD3 | ENSCAFP00000000924 | ENSCAFP00000012176 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.577 |
FZD6 | FZD4 | ENSCAFP00000000924 | ENSCAFP00000053452 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.607 |
FZD6 | LRP5 | ENSCAFP00000000924 | ENSCAFP00000016050 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.966 |
FZD6 | WNT6 | ENSCAFP00000000924 | ENSCAFP00000038712 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.956 |
GPC3 | WNT6 | ENSCAFP00000027825 | ENSCAFP00000038712 | Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.929 |