node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL1 | CCL17 | ENSCAFP00000048804 | ENSCAFP00000048446 | C-C motif chemokine. | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). | 0.798 |
CCL1 | CCL22 | ENSCAFP00000048804 | ENSCAFP00000036847 | C-C motif chemokine. | C-C motif chemokine. | 0.691 |
CCL1 | CCL26 | ENSCAFP00000048804 | ENSCAFP00000040578 | C-C motif chemokine. | C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils. | 0.638 |
CCL1 | CCL4 | ENSCAFP00000048804 | ENSCAFP00000045688 | C-C motif chemokine. | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | 0.628 |
CCL1 | CCL5 | ENSCAFP00000048804 | ENSCAFP00000063573 | C-C motif chemokine. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.636 |
CCL1 | CCL8 | ENSCAFP00000048804 | ENSCAFP00000027105 | C-C motif chemokine. | C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity). | 0.524 |
CCL1 | CCR3 | ENSCAFP00000048804 | ENSCAFP00000020344 | C-C motif chemokine. | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | 0.891 |
CCL1 | CCR5 | ENSCAFP00000048804 | ENSCAFP00000020323 | C-C motif chemokine. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.866 |
CCL1 | CCR8 | ENSCAFP00000048804 | ENSCAFP00000039111 | C-C motif chemokine. | C-C motif chemokine receptor 8. | 0.974 |
CCL17 | CCL1 | ENSCAFP00000048446 | ENSCAFP00000048804 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). | C-C motif chemokine. | 0.798 |
CCL17 | CCL22 | ENSCAFP00000048446 | ENSCAFP00000036847 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). | C-C motif chemokine. | 0.992 |
CCL17 | CCL26 | ENSCAFP00000048446 | ENSCAFP00000040578 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). | C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils. | 0.980 |
CCL17 | CCL4 | ENSCAFP00000048446 | ENSCAFP00000045688 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | 0.728 |
CCL17 | CCL5 | ENSCAFP00000048446 | ENSCAFP00000063573 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.997 |
CCL17 | CCL8 | ENSCAFP00000048446 | ENSCAFP00000027105 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). | C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity). | 0.591 |
CCL17 | CCR3 | ENSCAFP00000048446 | ENSCAFP00000020344 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | 0.893 |
CCL17 | CCR5 | ENSCAFP00000048446 | ENSCAFP00000020323 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.836 |
CCL17 | CCR8 | ENSCAFP00000048446 | ENSCAFP00000039111 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). | C-C motif chemokine receptor 8. | 0.880 |
CCL17 | FOXP3 | ENSCAFP00000048446 | ENSCAFP00000023435 | C-C motif chemokine 17; Chemotactic factor for t lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 and CCR8 (By similarity). | Forkhead box P3. | 0.534 |
CCL22 | CCL1 | ENSCAFP00000036847 | ENSCAFP00000048804 | C-C motif chemokine. | C-C motif chemokine. | 0.691 |