PLAA protein (Canis lupus familiaris) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

PLAA

Phospholipase A2 activating protein. (796 aa)

Predicted Functional Partners:

UFD1

0.972

YOD1

0.968

NPLOC4

0.889

FAAP100

0.887

NSFL1C

0.885

VCP

0.883

UBXN2B

0.874

UBB

0.846

LOC100685053

0.845

UBXN1

0.808

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAAP100	LOC100685053	ENSCAFP00000008608	ENSCAFP00000066632	FA core complex associated protein 100.	Ubiquitin-like domain-containing protein.	0.734
FAAP100	NSFL1C	ENSCAFP00000008608	ENSCAFP00000010130	FA core complex associated protein 100.	NSFL1 cofactor.	0.748
FAAP100	PLAA	ENSCAFP00000008608	ENSCAFP00000039332	FA core complex associated protein 100.	Phospholipase A2 activating protein.	0.887
FAAP100	UBB	ENSCAFP00000008608	ENSCAFP00000063279	FA core complex associated protein 100.	Ubiquitin B.	0.861
FAAP100	UBXN2B	ENSCAFP00000008608	ENSCAFP00000010519	FA core complex associated protein 100.	UBX domain protein 2B.	0.606
FAAP100	UFD1	ENSCAFP00000008608	ENSCAFP00000038321	FA core complex associated protein 100.	Ubiquitin recognition factor in ER associated degradation 1.	0.895
FAAP100	VCP	ENSCAFP00000008608	ENSCAFP00000002927	FA core complex associated protein 100.	Valosin containing protein; Belongs to the AAA ATPase family.	0.796
FAAP100	YOD1	ENSCAFP00000008608	ENSCAFP00000016941	FA core complex associated protein 100.	YOD1 deubiquitinase.	0.864
LOC100685053	FAAP100	ENSCAFP00000066632	ENSCAFP00000008608	Ubiquitin-like domain-containing protein.	FA core complex associated protein 100.	0.734
LOC100685053	NPLOC4	ENSCAFP00000066632	ENSCAFP00000008625	Ubiquitin-like domain-containing protein.	NPL4 homolog, ubiquitin recognition factor.	0.734
LOC100685053	NSFL1C	ENSCAFP00000066632	ENSCAFP00000010130	Ubiquitin-like domain-containing protein.	NSFL1 cofactor.	0.467
LOC100685053	PLAA	ENSCAFP00000066632	ENSCAFP00000039332	Ubiquitin-like domain-containing protein.	Phospholipase A2 activating protein.	0.845
LOC100685053	UBXN2B	ENSCAFP00000066632	ENSCAFP00000010519	Ubiquitin-like domain-containing protein.	UBX domain protein 2B.	0.467
LOC100685053	UFD1	ENSCAFP00000066632	ENSCAFP00000038321	Ubiquitin-like domain-containing protein.	Ubiquitin recognition factor in ER associated degradation 1.	0.804
LOC100685053	VCP	ENSCAFP00000066632	ENSCAFP00000002927	Ubiquitin-like domain-containing protein.	Valosin containing protein; Belongs to the AAA ATPase family.	0.620
LOC100685053	YOD1	ENSCAFP00000066632	ENSCAFP00000016941	Ubiquitin-like domain-containing protein.	YOD1 deubiquitinase.	0.823
NPLOC4	LOC100685053	ENSCAFP00000008625	ENSCAFP00000066632	NPL4 homolog, ubiquitin recognition factor.	Ubiquitin-like domain-containing protein.	0.734
NPLOC4	NSFL1C	ENSCAFP00000008625	ENSCAFP00000010130	NPL4 homolog, ubiquitin recognition factor.	NSFL1 cofactor.	0.945
NPLOC4	PLAA	ENSCAFP00000008625	ENSCAFP00000039332	NPL4 homolog, ubiquitin recognition factor.	Phospholipase A2 activating protein.	0.889
NPLOC4	UBB	ENSCAFP00000008625	ENSCAFP00000063279	NPL4 homolog, ubiquitin recognition factor.	Ubiquitin B.	0.861

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.841

expected number of edges:

16

PPI enrichment p-value:

3.86e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

8 of 82

1.26

1.64

5.36e-07

GO:0007165

Signal transduction

9 of 122

1.14

1.4

5.36e-07

GO:0019538

Protein metabolic process

8 of 194

0.88

0.84

5.34e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 39

1.52

2.26

1.94e-07

GO:0000155

Phosphorelay sensor kinase activity

6 of 35

1.5

2.0

2.21e-06

GO:0140096

Catalytic activity, acting on a protein

9 of 109

1.19

1.54

1.80e-07

GO:0016740

Transferase activity

8 of 304

0.69

0.54

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2313

Phosphorelay signal transduction system, and GGDEF domain

6 of 72

1.19

1.17

0.00018

CL:2397

PAC motif, and Putative diguanylate phosphodiesterase

3 of 12

1.67

1.17

0.0034

CL:2309

Signal transduction, and Flagellar assembly

8 of 171

0.94

0.87

0.00018

CL:2400

Mixed, incl. PAS domain, and SsuA/THI5-like

2 of 6

1.79

0.78

0.0310

CL:2317

Phosphorelay signal transduction system

3 of 29

1.28

0.7

0.0250

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

5 of 58

1.2

0.98

0.0019

KW-0597

Phosphoprotein

5 of 63

1.17

0.95

0.0019

KW-0175

Coiled coil

7 of 254

0.71

0.51

0.0070

KW-0808

Transferase

6 of 237

0.67

0.4

0.0359

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 29

1.65

2.73

2.51e-08

IPR003594

Histidine kinase/HSP90-like ATPase

8 of 40

1.57

2.65

6.63e-09

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

8 of 41

1.56

2.62

6.63e-09

IPR005467

Histidine kinase domain

7 of 37

1.55

2.38

8.52e-08

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

6 of 35

1.5

1.96

3.24e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

8 of 39

1.58

2.89

4.69e-10

SM00388

His Kinase A (phosphoacceptor) domain

5 of 35

1.42

1.61

3.40e-05

SM00448

cheY-homologous receiver domain

5 of 55

1.23

1.21

0.00018

SM00091

PAS domain

3 of 21

1.42

1.03

0.0040

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 21

1.42

1.03

0.0040

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