STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPR83Probable G-protein coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor; Belongs to the G-protein coupled receptor 1 family. (422 aa)    
Predicted Functional Partners:
NPY
Neuropeptide Y.
    
 0.927
PPY
Pancreatic icosapeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
   
  0.903
IRS4
Insulin receptor substrate 4.
   
  0.901
IRS2
Insulin receptor substrate 2.
   
  0.900
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
 
  0.900
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
   
 
  0.900
TECRL
Trans-2,3-enoyl-CoA reductase like.
      
 0.740
MRAP2
Melanocortin 2 receptor accessory protein 2.
  
  
 0.737
QRFP
Pyroglutamylated RFamide peptide.
      
 0.706
GPR157
G protein-coupled receptor 157.
   
  
 0.676
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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