STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
D2HGDHD-2-hydroxyglutarate dehydrogenase. (387 aa)    
Predicted Functional Partners:
L2HGDH
L-2-hydroxyglutarate dehydrogenase.
      
 0.882
DMAP1
DNA methyltransferase 1 associated protein 1.
   
 
 0.799
TRRAP
Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family.
   
 
 0.799
MAT2B
Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.
 
    
 0.795
ADHFE1
Alcohol dehydrogenase iron containing 1.
   
  
 0.790
MEAF6
MYST/Esa1 associated factor 6.
   
 
 0.780
YEATS4
YEATS domain containing 4.
   
 
 0.749
SLC22A8
Solute carrier family 22 member 8.
      
 0.712
EPC1
Enhancer of polycomb homolog.
   
 
 0.679
EPC2
Enhancer of polycomb homolog.
   
 
 0.679
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.