PPBP protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

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[Homology]

Score

PPBP

SCY domain-containing protein. (118 aa)

Predicted Functional Partners:

CXCL10

0.987

CXCL12

0.985

CXCL6

0.975

CXCR2

0.966

CCL5

0.964

CCL13

0.952

CCL26

0.950

CXCL14

0.949

CXCL8

0.940

CCL28

0.933

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL13	CCL26	ENSCAFP00000032928	ENSCAFP00000040578	C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family.	C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils.	0.944
CCL13	CCL28	ENSCAFP00000032928	ENSCAFP00000031374	C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family.	C-C motif chemokine 28; Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner (By similarity); Belongs to the intercrine beta (chemokine CC) family.	0.931
CCL13	CCL5	ENSCAFP00000032928	ENSCAFP00000063573	C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.957
CCL13	CXCL10	ENSCAFP00000032928	ENSCAFP00000032015	C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family.	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	0.963
CCL13	CXCL12	ENSCAFP00000032928	ENSCAFP00000037130	C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family.	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.956
CCL13	CXCL14	ENSCAFP00000032928	ENSCAFP00000001519	C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family.	C-X-C motif chemokine ligand 14.	0.935
CCL13	CXCL6	ENSCAFP00000032928	ENSCAFP00000034480	C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family.	C-X-C motif chemokine.	0.417
CCL13	PPBP	ENSCAFP00000032928	ENSCAFP00000039975	C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family.	SCY domain-containing protein.	0.952
CCL26	CCL13	ENSCAFP00000040578	ENSCAFP00000032928	C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils.	C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family.	0.944
CCL26	CCL28	ENSCAFP00000040578	ENSCAFP00000031374	C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils.	C-C motif chemokine 28; Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner (By similarity); Belongs to the intercrine beta (chemokine CC) family.	0.993
CCL26	CCL5	ENSCAFP00000040578	ENSCAFP00000063573	C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.995
CCL26	CXCL10	ENSCAFP00000040578	ENSCAFP00000032015	C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils.	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	0.959
CCL26	CXCL12	ENSCAFP00000040578	ENSCAFP00000037130	C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils.	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.954
CCL26	CXCL14	ENSCAFP00000040578	ENSCAFP00000001519	C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils.	C-X-C motif chemokine ligand 14.	0.951
CCL26	CXCL6	ENSCAFP00000040578	ENSCAFP00000034480	C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils.	C-X-C motif chemokine.	0.761
CCL26	CXCR2	ENSCAFP00000040578	ENSCAFP00000021547	C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils.	C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity).	0.715
CCL26	PPBP	ENSCAFP00000040578	ENSCAFP00000039975	C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils.	SCY domain-containing protein.	0.950
CCL28	CCL13	ENSCAFP00000031374	ENSCAFP00000032928	C-C motif chemokine 28; Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner (By similarity); Belongs to the intercrine beta (chemokine CC) family.	C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors (By similarity); Belongs to the intercrine beta (chemokine CC) family.	0.931
CCL28	CCL26	ENSCAFP00000031374	ENSCAFP00000040578	C-C motif chemokine 28; Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner (By similarity); Belongs to the intercrine beta (chemokine CC) family.	C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers (Ca2+) mobilization in eosinophils.	0.993
CCL28	CCL5	ENSCAFP00000031374	ENSCAFP00000063573	C-C motif chemokine 28; Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner (By similarity); Belongs to the intercrine beta (chemokine CC) family.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.993