Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TBC1D20TBC1 domain family member 20. (403 aa)    
Predicted Functional Partners:
RAB3GAP2
RAB3 GTPase activating non-catalytic protein subunit 2.
      
 0.929
RAB18
RAB18, member RAS oncogene family.
      
 0.882
RAB3GAP1
RAB3 GTPase activating protein catalytic subunit 1.
      
 0.861
RAB1A
Ras-related protein Rab-1A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secreti [...]
    
 0.854
RAB1B
RAB1B, member RAS oncogene family.
   
 
 0.778
TBC1D2
TBC1 domain family member 2.
   
  
 0.731
DENND1B
DENN domain containing 1B.
      
 0.671
TBC1D21
TBC1 domain family member 21.
   
  
 0.620
TBC1D7
TBC1 domain family member 7.
      
 0.615
TBC1D16
TBC1 domain family member 16.
      
 0.609
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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