STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WNK3WNK lysine deficient protein kinase 3. (2294 aa)    
Predicted Functional Partners:
OXSR1
Oxidative stress responsive kinase 1.
    
 
0.735
BSPRY
B-box and SPRY domain containing.
      
 0.703
KLHL3
Kelch like family member 3.
   
 
 0.674
MARCHF9
Membrane associated ring-CH-type finger 9.
      
 0.619
JUND
JunD proto-oncogene, AP-1 transcription factor subunit.
    
 
 0.612
JUNB
JunB proto-oncogene, AP-1 transcription factor subunit.
    
 
 0.612
KLHL2
Kelch like family member 2.
    
 
 0.605
PNPLA8
Patatin like phospholipase domain containing 8.
    
 
 0.595
TRPV5
Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family.
    
 
 0.568
MED17
Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 
 0.557
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.