ZFP90 protein (Canis lupus familiaris) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

ZFP90

ZFP90 zinc finger protein. (758 aa)

Predicted Functional Partners:

LRGUK

0.744

MTPN

0.664

HNF1A

0.515

ANKRD6

0.511

BPTF

0.510

JAZF1

0.484

MEX3A

0.463

RBBP4

0.457

ENSCAFP00000058271

0.457

FEV

0.435

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD6	ZFP90	ENSCAFP00000060941	ENSCAFP00000041072	Ankyrin repeat domain 6.	ZFP90 zinc finger protein.	0.511
BPTF	ENSCAFP00000058271	ENSCAFP00000057652	ENSCAFP00000058271	Bromodomain PHD finger transcription factor.	WD_REPEATS_REGION domain-containing protein.	0.651
BPTF	RBBP4	ENSCAFP00000057652	ENSCAFP00000049784	Bromodomain PHD finger transcription factor.	RB binding protein 4, chromatin remodeling factor.	0.839
BPTF	ZFP90	ENSCAFP00000057652	ENSCAFP00000041072	Bromodomain PHD finger transcription factor.	ZFP90 zinc finger protein.	0.510
ENSCAFP00000058271	BPTF	ENSCAFP00000058271	ENSCAFP00000057652	WD_REPEATS_REGION domain-containing protein.	Bromodomain PHD finger transcription factor.	0.651
ENSCAFP00000058271	ZFP90	ENSCAFP00000058271	ENSCAFP00000041072	WD_REPEATS_REGION domain-containing protein.	ZFP90 zinc finger protein.	0.457
FEV	ZFP90	ENSCAFP00000065580	ENSCAFP00000041072	Uncharacterized protein.	ZFP90 zinc finger protein.	0.435
HNF1A	ZFP90	ENSCAFP00000015433	ENSCAFP00000041072	HNF1 homeobox A.	ZFP90 zinc finger protein.	0.515
JAZF1	ZFP90	ENSCAFP00000055437	ENSCAFP00000041072	JAZF zinc finger 1.	ZFP90 zinc finger protein.	0.484
LRGUK	MTPN	ENSCAFP00000001870	ENSCAFP00000039244	Leucine rich repeats and guanylate kinase domain containing.	Myotrophin; Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity).	0.463
LRGUK	ZFP90	ENSCAFP00000001870	ENSCAFP00000041072	Leucine rich repeats and guanylate kinase domain containing.	ZFP90 zinc finger protein.	0.744
MEX3A	ZFP90	ENSCAFP00000020283	ENSCAFP00000041072	Mex-3 RNA binding family member A.	ZFP90 zinc finger protein.	0.463
MTPN	LRGUK	ENSCAFP00000039244	ENSCAFP00000001870	Myotrophin; Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity).	Leucine rich repeats and guanylate kinase domain containing.	0.463
MTPN	ZFP90	ENSCAFP00000039244	ENSCAFP00000041072	Myotrophin; Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity).	ZFP90 zinc finger protein.	0.664
RBBP4	BPTF	ENSCAFP00000049784	ENSCAFP00000057652	RB binding protein 4, chromatin remodeling factor.	Bromodomain PHD finger transcription factor.	0.839
RBBP4	ZFP90	ENSCAFP00000049784	ENSCAFP00000041072	RB binding protein 4, chromatin remodeling factor.	ZFP90 zinc finger protein.	0.457
ZFP90	ANKRD6	ENSCAFP00000041072	ENSCAFP00000060941	ZFP90 zinc finger protein.	Ankyrin repeat domain 6.	0.511
ZFP90	BPTF	ENSCAFP00000041072	ENSCAFP00000057652	ZFP90 zinc finger protein.	Bromodomain PHD finger transcription factor.	0.510
ZFP90	ENSCAFP00000058271	ENSCAFP00000041072	ENSCAFP00000058271	ZFP90 zinc finger protein.	WD_REPEATS_REGION domain-containing protein.	0.457
ZFP90	FEV	ENSCAFP00000041072	ENSCAFP00000065580	ZFP90 zinc finger protein.	Uncharacterized protein.	0.435

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Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.894

expected number of edges:

14

PPI enrichment p-value:

0.000604

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006401

RNA catabolic process

4 of 12

2.05

2.0

0.00010

GO:0016070

RNA metabolic process

5 of 156

1.04

0.69

0.0104

GO:1901575

Organic substance catabolic process

5 of 225

0.88

0.49

0.0365

GO:0006139

Nucleobase-containing compound metabolic process

7 of 461

0.71

0.47

0.0168

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003724

RNA helicase activity

3 of 3

2.53

1.93

0.00027

GO:0004386

Helicase activity

4 of 21

1.81

1.69

0.00027

GO:0140657

ATP-dependent activity

5 of 135

1.1

0.81

0.0048

GO:0140098

Catalytic activity, acting on RNA

4 of 96

1.15

0.7

0.0166

GO:0140640

Catalytic activity, acting on a nucleic acid

5 of 174

0.99

0.65

0.0126

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30678639

(2019) Transcriptome analysis of genes and metabolic pathways associated with nicotine degradation in Aspergillus oryzae 112822.

3 of 9

2.05

1.44

0.0016

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

7 of 28

1.93

3.99

1.37e-10

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0347

Helicase

3 of 17

1.78

1.15

0.0047

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014014

RNA helicase, DEAD-box type, Q motif

3 of 3

2.53

1.76

0.00055

IPR000629

ATP-dependent RNA helicase DEAD-box, conserved site

3 of 3

2.53

1.76

0.00055

IPR011545

DEAD/DEAH box helicase domain

3 of 8

2.11

1.47

0.0015

IPR014001

Helicase superfamily 1/2, ATP-binding domain

3 of 12

1.93

1.28

0.0031

IPR001650

Helicase, C-terminal

3 of 12

1.93

1.28

0.0031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00487

DEAD-like helicases superfamily

4 of 13

2.02

2.41

1.01e-05

SM00490

Helicase superfamily c-terminal domain

4 of 15

1.96

2.36

1.01e-05

SM00316

Ribosomal protein S1-like RNA-binding domain

2 of 9

1.88

0.94

0.0153

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