STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPINT3Early lactation protein. (100 aa)    
Predicted Functional Partners:
TP53TG5
TP53 target 5.
      
 0.720
WFDC8
WAP four-disulfide core domain 8.
      
 0.707
SYS1
Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family.
   
  
 0.683
SPINT4
Serine peptidase inhibitor, Kunitz type 4.
      
 0.678
ELP3
Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.
      
 0.676
DTNBP1
Dystrobrevin binding protein 1.
      
 0.641
WFDC2
WAP four-disulfide core domain protein 2; Broad range protease inhibitor (By similarity). Possible function in sperm maturation.
    
 
 0.589
CSN2
Beta-casein; Important role in determination of the surface properties of the casein micelles.
   
  
 0.583
HGFAC
Hepatocyte growth factor activator short chain; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form; Belongs to the peptidase S1 family.
    
 
 0.554
SPINT1
Serine peptidase inhibitor, Kunitz type 1.
   
  
 0.511
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.