node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALKAL1 | C11H9orf72 | ENSCAFP00000058521 | ENSCAFP00000002503 | RB1 inducible coiled-coil 1. | Chromosome 11 C9orf72 homolog. | 0.937 |
ALKAL1 | SMCR8 | ENSCAFP00000058521 | ENSCAFP00000026969 | RB1 inducible coiled-coil 1. | SMCR8-C9orf72 complex subunit. | 0.571 |
ALKAL1 | WDR41 | ENSCAFP00000058521 | ENSCAFP00000041138 | RB1 inducible coiled-coil 1. | WD repeat domain 41. | 0.682 |
ARF5 | RAB5A | ENSCAFP00000002515 | ENSCAFP00000008690 | ADP ribosylation factor 5; Belongs to the small GTPase superfamily. Arf family. | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.564 |
ARF5 | WDR41 | ENSCAFP00000002515 | ENSCAFP00000041138 | ADP ribosylation factor 5; Belongs to the small GTPase superfamily. Arf family. | WD repeat domain 41. | 0.816 |
ARL8B | WDR41 | ENSCAFP00000008385 | ENSCAFP00000041138 | ADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family. | WD repeat domain 41. | 0.818 |
C11H9orf72 | ALKAL1 | ENSCAFP00000002503 | ENSCAFP00000058521 | Chromosome 11 C9orf72 homolog. | RB1 inducible coiled-coil 1. | 0.937 |
C11H9orf72 | RAB39B | ENSCAFP00000002503 | ENSCAFP00000036618 | Chromosome 11 C9orf72 homolog. | RAB39B, member RAS oncogene family. | 0.907 |
C11H9orf72 | RAB8A | ENSCAFP00000002503 | ENSCAFP00000023207 | Chromosome 11 C9orf72 homolog. | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | 0.919 |
C11H9orf72 | SMCR8 | ENSCAFP00000002503 | ENSCAFP00000026969 | Chromosome 11 C9orf72 homolog. | SMCR8-C9orf72 complex subunit. | 0.984 |
C11H9orf72 | WDR41 | ENSCAFP00000002503 | ENSCAFP00000041138 | Chromosome 11 C9orf72 homolog. | WD repeat domain 41. | 0.994 |
CKS1B | WDR41 | ENSCAFP00000060934 | ENSCAFP00000041138 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. | WD repeat domain 41. | 0.701 |
DENND1B | RAB5A | ENSCAFP00000016716 | ENSCAFP00000008690 | DENN domain containing 1B. | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.448 |
DENND1B | WDR41 | ENSCAFP00000016716 | ENSCAFP00000041138 | DENN domain containing 1B. | WD repeat domain 41. | 0.649 |
RAB39B | C11H9orf72 | ENSCAFP00000036618 | ENSCAFP00000002503 | RAB39B, member RAS oncogene family. | Chromosome 11 C9orf72 homolog. | 0.907 |
RAB39B | RAB8A | ENSCAFP00000036618 | ENSCAFP00000023207 | RAB39B, member RAS oncogene family. | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | 0.914 |
RAB39B | WDR41 | ENSCAFP00000036618 | ENSCAFP00000041138 | RAB39B, member RAS oncogene family. | WD repeat domain 41. | 0.917 |
RAB5A | ARF5 | ENSCAFP00000008690 | ENSCAFP00000002515 | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | ADP ribosylation factor 5; Belongs to the small GTPase superfamily. Arf family. | 0.564 |
RAB5A | DENND1B | ENSCAFP00000008690 | ENSCAFP00000016716 | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | DENN domain containing 1B. | 0.448 |
RAB5A | WDR41 | ENSCAFP00000008690 | ENSCAFP00000041138 | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | WD repeat domain 41. | 0.672 |