STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC608680UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)    
Predicted Functional Partners:
UBE2V2
Ubiquitin conjugating enzyme E2 V2.
   
 
 0.854
LGALS7
Galectin.
      
 0.818
TRIP12
Thyroid hormone receptor interactor 12.
   
 
 0.781
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
   
 
 0.766
UBE2V1
Ubiquitin conjugating enzyme E2 V1.
   
 
 0.755
ENSCAFP00000053186
annotation not available
   
 
 0.755
ENSCAFP00000047437
Uncharacterized protein.
   
 
 0.710
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 
 0.694
UBB
Ubiquitin B.
   
 
 0.668
LOC100685053
Ubiquitin-like domain-containing protein.
   
 
 0.668
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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