STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HIC2HIC ZBTB transcriptional repressor 2. (616 aa)    
Predicted Functional Partners:
ASXL3
ASXL transcriptional regulator 3.
   
 
 0.586
RNF2
Ring finger protein 2.
      
 0.517
VSIG2
V-set and immunoglobulin domain containing 2.
   
  
 0.500
SGK2
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 
 0.484
KCNU1
Potassium calcium-activated channel subfamily U member 1.
   
  
 0.481
TBC1D16
TBC1 domain family member 16.
   
  
 0.432
SLC37A1
Solute carrier family 37 member 1.
    
 
 0.420
KCNS1
Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family.
   
  
 0.411
MPP5
MAGUK p55 subfamily member 5; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells. Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface. Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebell [...]
    
 
 0.403
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.