ZNF568 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ZNF568

Uncharacterized protein. (688 aa)

Predicted Functional Partners:

CYP20A1

0.486

KLHDC1

0.466

ZC3H8

0.429

C15H12orf50

0.407

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C15H12orf50	ZNF568	ENSCAFP00000049761	ENSCAFP00000042031	Chromosome 15 C12orf50 homolog.	Uncharacterized protein.	0.407
CYP20A1	ZNF568	ENSCAFP00000018794	ENSCAFP00000042031	Cytochrome P450 family 20 subfamily A member 1.	Uncharacterized protein.	0.486
KLHDC1	ZNF568	ENSCAFP00000020944	ENSCAFP00000042031	Kelch domain containing 1.	Uncharacterized protein.	0.466
ZC3H8	ZNF568	ENSCAFP00000054436	ENSCAFP00000042031	Zinc finger CCCH-type containing 8.	Uncharacterized protein.	0.429
ZNF568	C15H12orf50	ENSCAFP00000042031	ENSCAFP00000049761	Uncharacterized protein.	Chromosome 15 C12orf50 homolog.	0.407
ZNF568	CYP20A1	ENSCAFP00000042031	ENSCAFP00000018794	Uncharacterized protein.	Cytochrome P450 family 20 subfamily A member 1.	0.486
ZNF568	KLHDC1	ENSCAFP00000042031	ENSCAFP00000020944	Uncharacterized protein.	Kelch domain containing 1.	0.466
ZNF568	ZC3H8	ENSCAFP00000042031	ENSCAFP00000054436	Uncharacterized protein.	Zinc finger CCCH-type containing 8.	0.429

Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.968

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

10 of 48

2.46

9.16

7.24e-21

GO:0006428

isoleucyl-tRNA aminoacylation

3 of 4

3.02

3.37

6.93e-07

GO:0006433

prolyl-tRNA aminoacylation

2 of 2

3.14

2.06

0.00019

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

9 of 47

2.43

8.0

3.99e-18

GO:0002161

aminoacyl-tRNA editing activity

4 of 11

2.71

3.97

3.48e-08

GO:0004822

isoleucine-tRNA ligase activity

3 of 4

3.02

3.19

1.50e-06

GO:0004827

proline-tRNA ligase activity

2 of 2

3.14

2.12

0.00015

GO:0005524

ATP binding

9 of 1375

0.96

1.04

2.49e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8312

Selenoamino acid metabolism, and tRNA-binding domain

11 of 16

2.98

14.25

1.05e-28

CL:8314

Cytosolic tRNA aminoacylation

9 of 10

3.1

12.12

9.77e-24

CL:8319

tRNA synthetases class I (E and Q), anti-codon binding domain, and prolyl-tRNA aminoacylation

5 of 5

3.14

6.29

2.64e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

10 of 61

2.36

8.83

3.40e-21

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-379716

Cytosolic tRNA aminoacylation

9 of 19

2.82

10.58

1.18e-21

MAP-379724

tRNA Aminoacylation

10 of 43

2.51

9.69

8.68e-22

MAP-2408522

Selenoamino acid metabolism

8 of 16

2.84

9.44

4.29e-19

MAP-72766

Translation

10 of 210

1.82

4.84

6.55e-16

MAP-71291

Metabolism of amino acids and derivatives

8 of 197

1.75

3.68

2.28e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017101

aminoacyl-tRNA synthetase multienzyme complex

4 of 10

2.75

3.71

1.22e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

4 of 20

2.45

3.36

3.38e-07

KW-0648

Protein biosynthesis

4 of 53

2.02

2.57

4.14e-06

KW-0820

tRNA-binding

2 of 10

2.45

1.5

0.0017

KW-0067

ATP-binding

4 of 635

0.94

0.53

0.0349

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09334

tRNA synthetases class I (M)

3 of 7

2.78

2.4

3.97e-05

PF03950

tRNA synthetases class I (E and Q), anti-codon binding domain

2 of 2

3.14

1.54

0.0017

PF01588

Putative tRNA binding domain

2 of 4

2.84

1.41

0.0028

PF03129

Anticodon binding domain

2 of 7

2.6

1.26

0.0051

PF08264

Anticodon-binding domain of tRNA ligase

2 of 9

2.49

1.2

0.0062

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold

6 of 60

2.14

3.8

7.64e-09

IPR001412

Aminoacyl-tRNA synthetase, class I, conserved site

4 of 15

2.57

3.2

9.25e-07

IPR023586

Isoleucine-tRNA ligase, type 2

3 of 3

3.14

2.87

6.14e-06

IPR002301

Isoleucine-tRNA ligase

3 of 4

3.02

2.8

8.05e-06

IPR009008

Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain

3 of 9

2.67

2.38

4.04e-05

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2025

Credits

Access

Info

About