STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRNShadow of prion protein. (147 aa)    
Predicted Functional Partners:
SYCE1
Synaptonemal complex central element protein 1.
      
 0.856
RASSF2
Ras association domain family member 2.
      
 0.696
PRND
Prion like protein doppel.
      
 0.682
PRNP
Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]
      
 0.520
AP5S1
Adaptor related protein complex 5 subunit sigma 1.
      
 0.515
CYP2E1
Cytochrome P450 2E1; Belongs to the cytochrome P450 family.
      
 0.511
MTG1
Mitochondrial ribosome associated GTPase 1.
      
 0.452
LY6G6D
Lymphocyte antigen 6 family member G6D.
     
  0.400
GPLD1
Glycosylphosphatidylinositol specific phospholipase D1.
     
  0.400
BST1
Bone marrow stromal cell antigen 1.
     
  0.400
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.