STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SYNCSyncoilin, intermediate filament protein; Belongs to the intermediate filament family. (472 aa)    
Predicted Functional Partners:
GALE
UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
      
 0.636
LRRN1
Leucine rich repeat neuronal 1.
   
 
 0.593
SETMAR
Uncharacterized protein.
    
 
 0.587
SYNM
Synemin; Belongs to the intermediate filament family.
   
 
 0.573
SYP
Synaptophysin.
   
 
 0.530
SUMF1
Sulfatase modifying factor 1.
   
 
 0.467
BHLHE40
Basic helix-loop-helix family member e40.
    
 
 0.438
FXN
Frataxin.
      
 0.437
ENSCAFP00000047935
IF rod domain-containing protein; Belongs to the intermediate filament family.
    
 
 0.420
DES
Desmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...]
    
 
0.420
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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