node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APBA3 | ENPP6 | ENSCAFP00000037390 | ENSCAFP00000055783 | Amyloid beta precursor protein binding family A member 3. | Ectonucleotide pyrophosphatase/phosphodiesterase 6. | 0.498 |
APBA3 | FBXL15 | ENSCAFP00000037390 | ENSCAFP00000014945 | Amyloid beta precursor protein binding family A member 3. | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. | 0.680 |
APBA3 | FBXW2 | ENSCAFP00000037390 | ENSCAFP00000005310 | Amyloid beta precursor protein binding family A member 3. | F-box and WD repeat domain containing 2. | 0.595 |
APBA3 | HCCS | ENSCAFP00000037390 | ENSCAFP00000017027 | Amyloid beta precursor protein binding family A member 3. | Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | 0.525 |
CUL1 | ENSCAFP00000049197 | ENSCAFP00000005151 | ENSCAFP00000049197 | Cullin 1; Belongs to the cullin family. | Uncharacterized protein; Belongs to the SKP1 family. | 0.843 |
CUL1 | ENSCAFP00000051783 | ENSCAFP00000005151 | ENSCAFP00000051783 | Cullin 1; Belongs to the cullin family. | Uncharacterized protein; Belongs to the SKP1 family. | 0.843 |
CUL1 | ENSCAFP00000063226 | ENSCAFP00000005151 | ENSCAFP00000063226 | Cullin 1; Belongs to the cullin family. | Uncharacterized protein; Belongs to the SKP1 family. | 0.843 |
CUL1 | FBXL15 | ENSCAFP00000005151 | ENSCAFP00000014945 | Cullin 1; Belongs to the cullin family. | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. | 0.828 |
CUL1 | FBXW2 | ENSCAFP00000005151 | ENSCAFP00000005310 | Cullin 1; Belongs to the cullin family. | F-box and WD repeat domain containing 2. | 0.856 |
CUL1 | SKP1 | ENSCAFP00000005151 | ENSCAFP00000001412 | Cullin 1; Belongs to the cullin family. | S-phase kinase associated protein 1; Belongs to the SKP1 family. | 0.999 |
ENPP6 | APBA3 | ENSCAFP00000055783 | ENSCAFP00000037390 | Ectonucleotide pyrophosphatase/phosphodiesterase 6. | Amyloid beta precursor protein binding family A member 3. | 0.498 |
ENPP6 | FBXL15 | ENSCAFP00000055783 | ENSCAFP00000014945 | Ectonucleotide pyrophosphatase/phosphodiesterase 6. | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. | 0.688 |
ENPP6 | FBXW2 | ENSCAFP00000055783 | ENSCAFP00000005310 | Ectonucleotide pyrophosphatase/phosphodiesterase 6. | F-box and WD repeat domain containing 2. | 0.672 |
ENPP6 | HCCS | ENSCAFP00000055783 | ENSCAFP00000017027 | Ectonucleotide pyrophosphatase/phosphodiesterase 6. | Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | 0.559 |
ENSCAFP00000049197 | CUL1 | ENSCAFP00000049197 | ENSCAFP00000005151 | Uncharacterized protein; Belongs to the SKP1 family. | Cullin 1; Belongs to the cullin family. | 0.843 |
ENSCAFP00000049197 | FBXL15 | ENSCAFP00000049197 | ENSCAFP00000014945 | Uncharacterized protein; Belongs to the SKP1 family. | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. | 0.731 |
ENSCAFP00000049197 | FBXW2 | ENSCAFP00000049197 | ENSCAFP00000005310 | Uncharacterized protein; Belongs to the SKP1 family. | F-box and WD repeat domain containing 2. | 0.605 |
ENSCAFP00000051783 | CUL1 | ENSCAFP00000051783 | ENSCAFP00000005151 | Uncharacterized protein; Belongs to the SKP1 family. | Cullin 1; Belongs to the cullin family. | 0.843 |
ENSCAFP00000051783 | FBXL15 | ENSCAFP00000051783 | ENSCAFP00000014945 | Uncharacterized protein; Belongs to the SKP1 family. | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. | 0.731 |
ENSCAFP00000051783 | FBXW2 | ENSCAFP00000051783 | ENSCAFP00000005310 | Uncharacterized protein; Belongs to the SKP1 family. | F-box and WD repeat domain containing 2. | 0.605 |