LY96 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LY96

Lymphocyte antigen 96. (160 aa)

Predicted Functional Partners:

TLR4

0.964

TLR2

0.910

MYD88

0.854

HMGB1

0.820

TRAF6

0.815

TLR7

0.747

TICAM2

0.745

TLR5

0.743

TLR3

0.732

TLR6

0.729

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HMGB1	LY96	ENSCAFP00000041181	ENSCAFP00000042952	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...]	Lymphocyte antigen 96.	0.820
HMGB1	MYD88	ENSCAFP00000041181	ENSCAFP00000007386	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...]	MYD88 innate immune signal transduction adaptor.	0.619
HMGB1	TLR2	ENSCAFP00000041181	ENSCAFP00000012269	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...]	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.936
HMGB1	TLR3	ENSCAFP00000041181	ENSCAFP00000044568	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...]	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.576
HMGB1	TLR4	ENSCAFP00000041181	ENSCAFP00000031395	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...]	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.936
HMGB1	TLR5	ENSCAFP00000041181	ENSCAFP00000016726	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...]	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.400
HMGB1	TLR6	ENSCAFP00000041181	ENSCAFP00000023836	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...]	Toll like receptor 6; Belongs to the Toll-like receptor family.	0.685
HMGB1	TLR7	ENSCAFP00000041181	ENSCAFP00000043898	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...]	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.516
LY96	HMGB1	ENSCAFP00000042952	ENSCAFP00000041181	Lymphocyte antigen 96.	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...]	0.820
LY96	MYD88	ENSCAFP00000042952	ENSCAFP00000007386	Lymphocyte antigen 96.	MYD88 innate immune signal transduction adaptor.	0.854
LY96	TICAM2	ENSCAFP00000042952	ENSCAFP00000000299	Lymphocyte antigen 96.	TIR domain-containing protein.	0.745
LY96	TLR2	ENSCAFP00000042952	ENSCAFP00000012269	Lymphocyte antigen 96.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.910
LY96	TLR3	ENSCAFP00000042952	ENSCAFP00000044568	Lymphocyte antigen 96.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.732
LY96	TLR4	ENSCAFP00000042952	ENSCAFP00000031395	Lymphocyte antigen 96.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.964
LY96	TLR5	ENSCAFP00000042952	ENSCAFP00000016726	Lymphocyte antigen 96.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.743
LY96	TLR6	ENSCAFP00000042952	ENSCAFP00000023836	Lymphocyte antigen 96.	Toll like receptor 6; Belongs to the Toll-like receptor family.	0.729
LY96	TLR7	ENSCAFP00000042952	ENSCAFP00000043898	Lymphocyte antigen 96.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.747
LY96	TRAF6	ENSCAFP00000042952	ENSCAFP00000010159	Lymphocyte antigen 96.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.815
MYD88	HMGB1	ENSCAFP00000007386	ENSCAFP00000041181	MYD88 innate immune signal transduction adaptor.	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...]	0.619
MYD88	LY96	ENSCAFP00000007386	ENSCAFP00000042952	MYD88 innate immune signal transduction adaptor.	Lymphocyte antigen 96.	0.854