STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CTSGGranzyme B; Belongs to the peptidase S1 family. (351 aa)    
Predicted Functional Partners:
ELANE
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
0.930
SERPINB6
Serpin family B member 6; Belongs to the serpin family.
   
 0.925
SERPINB10
Serpin family B member 10; Belongs to the serpin family.
   
 0.920
SERPINB13
Serpin family B member 13; Belongs to the serpin family.
   
 0.920
E2R033_CANLF
SERPIN domain-containing protein; Belongs to the serpin family.
   
 0.920
CTRB2
Chymotrypsin 2 chain A; Belongs to the peptidase S1 family.
  
0.888
AGT
Angiotensinogen; Belongs to the serpin family.
   
 0.879
MMP9
Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).
   
 0.876
CASP4
Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]
   
 0.853
MPO
Myeloperoxidase.
   
 
 0.814
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.