MC3R protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

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Score

MC3R

Melanocortin-3 receptor. (323 aa)

Predicted Functional Partners:

POMC

0.988

AGRP

0.926

MRAP2

0.775

CBLN4

0.656

NPY

0.609

LEP

0.600

PCSK1

0.585

GHRL

0.570

MCFD2

0.563

MRAP

0.548

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRP	GHRL	ENSCAFP00000030191	ENSCAFP00000007641	Agouti related neuropeptide.	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	0.891
AGRP	LEP	ENSCAFP00000030191	ENSCAFP00000002433	Agouti related neuropeptide.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.883
AGRP	MC3R	ENSCAFP00000030191	ENSCAFP00000043232	Agouti related neuropeptide.	Melanocortin-3 receptor.	0.926
AGRP	MRAP2	ENSCAFP00000030191	ENSCAFP00000053573	Agouti related neuropeptide.	Melanocortin 2 receptor accessory protein 2.	0.558
AGRP	NPY	ENSCAFP00000030191	ENSCAFP00000004135	Agouti related neuropeptide.	Neuropeptide Y.	0.922
AGRP	PCSK1	ENSCAFP00000030191	ENSCAFP00000011663	Agouti related neuropeptide.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.483
AGRP	POMC	ENSCAFP00000030191	ENSCAFP00000006163	Agouti related neuropeptide.	Proopiomelanocortin.	0.936
CBLN4	MC3R	ENSCAFP00000017487	ENSCAFP00000043232	Cerebellin 4 precursor.	Melanocortin-3 receptor.	0.656
GHRL	AGRP	ENSCAFP00000007641	ENSCAFP00000030191	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	Agouti related neuropeptide.	0.891
GHRL	LEP	ENSCAFP00000007641	ENSCAFP00000002433	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.985
GHRL	MC3R	ENSCAFP00000007641	ENSCAFP00000043232	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	Melanocortin-3 receptor.	0.570
GHRL	MRAP2	ENSCAFP00000007641	ENSCAFP00000053573	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	Melanocortin 2 receptor accessory protein 2.	0.416
GHRL	NPY	ENSCAFP00000007641	ENSCAFP00000004135	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	Neuropeptide Y.	0.916
GHRL	PCSK1	ENSCAFP00000007641	ENSCAFP00000011663	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.826
GHRL	POMC	ENSCAFP00000007641	ENSCAFP00000006163	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	Proopiomelanocortin.	0.983
LEP	AGRP	ENSCAFP00000002433	ENSCAFP00000030191	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Agouti related neuropeptide.	0.883
LEP	GHRL	ENSCAFP00000002433	ENSCAFP00000007641	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	0.985
LEP	MC3R	ENSCAFP00000002433	ENSCAFP00000043232	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Melanocortin-3 receptor.	0.600
LEP	NPY	ENSCAFP00000002433	ENSCAFP00000004135	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Neuropeptide Y.	0.897
LEP	PCSK1	ENSCAFP00000002433	ENSCAFP00000011663	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.538