STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LDLRLow density lipoprotein receptor. (888 aa)    
Predicted Functional Partners:
LDLRAP1
Low density lipoprotein receptor adaptor protein 1.
    
 0.977
MYLIP
Myosin regulatory light chain interacting protein.
    
 0.953
DAB2
DAB adaptor protein 2.
    
 0.921
APOB
Apolipoprotein B.
    
 0.917
LIPC
PLAT domain-containing protein.
    
 0.778
HMGCS1
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.670
RELN
Reelin.
    
 
 0.632
EGFR
Receptor protein-tyrosine kinase.
   
 0.592
DVL2
Dishevelled segment polarity protein 2.
   
 0.585
SYT1
Synaptotagmin 1.
    
 0.569
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.