STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC102151858Rab-GAP TBC domain-containing protein. (267 aa)    
Predicted Functional Partners:
RAB5B
RAB5B, member RAS oncogene family.
    
 0.558
RAB5A
Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...]
    
 0.558
RAB5C
Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family.
    
 0.558
RABGEF1
RAB guanine nucleotide exchange factor 1.
   
 0.530
RABEP1
Rabaptin, RAB GTPase binding effector protein 1.
     
 0.525
GGA2
Golgi associated, gamma adaptin ear containing, ARF binding protein 2.
    
  0.507
GGA1
Golgi associated, gamma adaptin ear containing, ARF binding protein 1.
    
  0.507
GGA3
Golgi associated, gamma adaptin ear containing, ARF binding protein 3.
    
  0.506
ZNF407
Zinc finger protein 407.
    
 
 0.410
IFIH1
Potassium voltage-gated channel subfamily H member 7.
      
 0.407
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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