LOC100686813 protein (Canis lupus familiaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC100686813

Uncharacterized protein. (80 aa)

Predicted Functional Partners:

ITSN2

0.603

LOC100856635

0.568

ITSN1

0.568

SCIN

0.536

ANKRD16

0.528

CYTH2

0.521

SSH2

0.517

GTF2H5

0.508

SAMD4A

0.505

NSMCE4A

0.493

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD16	LOC100686813	ENSCAFP00000007804	ENSCAFP00000043877	Ankyrin repeat domain 16.	Uncharacterized protein.	0.528
ANKRD16	NSMCE4A	ENSCAFP00000007804	ENSCAFP00000018291	Ankyrin repeat domain 16.	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	0.684
CYTH2	LOC100686813	ENSCAFP00000005928	ENSCAFP00000043877	Cytohesin 2.	Uncharacterized protein.	0.521
GTF2H5	LOC100686813	ENSCAFP00000036445	ENSCAFP00000043877	General transcription factor IIH subunit 5.	Uncharacterized protein.	0.508
GTF2H5	SAMD4A	ENSCAFP00000036445	ENSCAFP00000035590	General transcription factor IIH subunit 5.	Sterile alpha motif domain containing 4A.	0.517
GTF2H5	SSH2	ENSCAFP00000036445	ENSCAFP00000038249	General transcription factor IIH subunit 5.	Slingshot protein phosphatase 2.	0.524
ITSN1	LOC100686813	ENSCAFP00000062904	ENSCAFP00000043877	Intersectin 1.	Uncharacterized protein.	0.568
ITSN2	LOC100686813	ENSCAFP00000006002	ENSCAFP00000043877	Intersectin 2.	Uncharacterized protein.	0.603
ITSN2	LOC100856635	ENSCAFP00000006002	ENSCAFP00000014017	Intersectin 2.	Uncharacterized protein.	0.623
LOC100686813	ANKRD16	ENSCAFP00000043877	ENSCAFP00000007804	Uncharacterized protein.	Ankyrin repeat domain 16.	0.528
LOC100686813	CYTH2	ENSCAFP00000043877	ENSCAFP00000005928	Uncharacterized protein.	Cytohesin 2.	0.521
LOC100686813	GTF2H5	ENSCAFP00000043877	ENSCAFP00000036445	Uncharacterized protein.	General transcription factor IIH subunit 5.	0.508
LOC100686813	ITSN1	ENSCAFP00000043877	ENSCAFP00000062904	Uncharacterized protein.	Intersectin 1.	0.568
LOC100686813	ITSN2	ENSCAFP00000043877	ENSCAFP00000006002	Uncharacterized protein.	Intersectin 2.	0.603
LOC100686813	LOC100856635	ENSCAFP00000043877	ENSCAFP00000014017	Uncharacterized protein.	Uncharacterized protein.	0.568
LOC100686813	NSMCE4A	ENSCAFP00000043877	ENSCAFP00000018291	Uncharacterized protein.	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.	0.493
LOC100686813	SAMD4A	ENSCAFP00000043877	ENSCAFP00000035590	Uncharacterized protein.	Sterile alpha motif domain containing 4A.	0.505
LOC100686813	SCIN	ENSCAFP00000043877	ENSCAFP00000044229	Uncharacterized protein.	Scinderin.	0.536
LOC100686813	SSH2	ENSCAFP00000043877	ENSCAFP00000038249	Uncharacterized protein.	Slingshot protein phosphatase 2.	0.517
LOC100856635	ITSN2	ENSCAFP00000014017	ENSCAFP00000006002	Uncharacterized protein.	Intersectin 2.	0.623

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

16

average node degree:

2.91

avg. local clustering coefficient:

0.867

expected number of edges:

10

PPI enrichment p-value:

0.0561

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071709

Membrane assembly

6 of 8

2.34

4.52

5.91e-10

GO:0043163

Cell envelope organization

6 of 8

2.34

4.52

5.91e-10

GO:0061024

Membrane organization

7 of 17

2.08

4.27

2.12e-10

GO:0015920

Lipopolysaccharide transport

5 of 5

2.46

4.08

1.06e-08

GO:0043165

Gram-negative-bacterium-type cell outer membrane assembly

5 of 7

2.32

3.77

2.77e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001530

Lipopolysaccharide binding

2 of 2

2.46

0.75

0.0432

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009279

Cell outer membrane

5 of 36

1.6

1.96

1.24e-05

GO:0098796

Membrane protein complex

5 of 51

1.45

1.71

1.79e-05

GO:1990063

Bam protein complex

2 of 3

2.29

1.54

0.0013

GO:0043190

ATP-binding cassette (ABC) transporter complex

3 of 18

1.68

1.48

0.00058

GO:0071944

Cell periphery

10 of 500

0.76

0.73

1.24e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2008

Lipid transport, and BolA protein

7 of 15

2.13

4.69

2.78e-11

CL:2025

Lipopolysaccharide transport

5 of 5

2.46

4.28

4.03e-09

CL:1942

Mixed, incl. Membrane organization, and Lipopolysaccharide biosynthesis

9 of 58

1.65

3.37

1.62e-11

CL:1940

Mixed, incl. Cell division, and Cellular component organization or biogenesis

10 of 159

1.26

1.97

1.87e-10

CL:1990

Mixed, incl. Bam protein complex, and Cell surface

2 of 7

1.92

0.78

0.0325

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

4 of 93

1.1

0.62

0.0262

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

3 of 8

2.04

1.78

0.00030

GOCC:0009279

Cell outer membrane

4 of 27

1.63

1.55

0.00030

GOCC:1990351

Transporter complex

4 of 33

1.55

1.48

0.00030

GOCC:0030313

Cell envelope

5 of 59

1.39

1.34

0.00030

GOCC:0016021

Integral component of membrane

4 of 108

1.03

0.72

0.0078

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0998

Cell outer membrane

4 of 9

2.11

2.46

1.10e-05

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