STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSCAFP00000043906J domain-containing protein. (358 aa)    
Predicted Functional Partners:
CDC5L
Cell division cycle 5 like.
   
 
 0.853
TFIP11
Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...]
   
 
 0.840
CRNKL1
Crooked neck pre-mRNA splicing factor 1.
   
 
 0.829
PLRG1
Pleiotropic regulator 1.
   
 
 0.824
PRPF19
Pre-mRNA processing factor 19.
   
 
 0.819
ANKRD9
Ankyrin repeat domain 9.
   
 
 0.803
IBTK
Inhibitor of Bruton tyrosine kinase.
    
 
 0.781
PPT1
Palmitoyl-protein thioesterase 1.
   
  
 0.755
SNW1
SNW domain containing 1.
    
 
 0.735
HSPA8
Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family.
  
 0.733
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.