STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSCAFP00000044560Uncharacterized protein. (175 aa)    
Predicted Functional Partners:
GRIN2B
Glutamate receptor ionotropic, NMDA 2B; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (By similarity). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator fo [...]
   
 
 0.627
KCNH1
Potassium voltage-gated channel subfamily H member 1.
    
 
 0.568
KCNH5
Potassium voltage-gated channel subfamily H member 5.
    
 
 0.568
LRRC7
Leucine rich repeat containing 7.
   
 
 0.525
GRIA1
Glutamate ionotropic receptor AMPA type subunit 1.
   
 
 0.521
CALM2
Calmodulin 1; Belongs to the calmodulin family.
   
 
 0.503
F1PIN6_CANLF
Uncharacterized protein; Belongs to the calmodulin family.
   
 
 0.503
J9NWJ7_CANLF
Uncharacterized protein; Belongs to the calmodulin family.
   
 
 0.503
J9NWQ5_CANLF
Uncharacterized protein; Belongs to the calmodulin family.
   
 
 0.503
CALM3
Calmodulin 3.
   
 
 0.503
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.