STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MCAMMelanoma cell adhesion molecule. (723 aa)    
Predicted Functional Partners:
KLHL35
Kelch like family member 35.
   
 
 0.540
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
     
 0.532
RHOC
Uncharacterized protein.
   
 0.523
RAC1
Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]
   
 0.515
RAC2
Rac family small GTPase 2.
   
 0.514
RHOG
Ras homolog family member G.
   
 0.514
RHOD
Ras homolog family member D.
    
 0.513
RHOB
Ras homolog family member B.
    
 0.513
RHOF
Ras homolog family member F, filopodia associated.
    
 0.513
TJP2
Tight junction protein ZO-2; Plays a role in tight junctions and adherens junctions; Belongs to the MAGUK family.
   
 0.500
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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