STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSCAFP00000045757Sushi domain-containing protein. (245 aa)    
Predicted Functional Partners:
CFH
Uncharacterized protein.
     
 
0.800
C3
Complement C3.
   
 0.747
CFHR5
Complement factor H related 5.
   
0.619
F12
Coagulation factor XII.
   
 
 0.569
DGKE
Diacylglycerol kinase.
      
 0.563
MMACHC
Metabolism of cobalamin associated C.
      
 0.548
THBD
Thrombomodulin; Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated (By similarity).
    
 
 0.532
CFB
Uncharacterized protein; Belongs to the peptidase S1 family.
    
 
 0.525
LOC484960
Anaphylatoxin-like domain-containing protein.
   
 
 0.516
LOC481722
Uncharacterized protein.
   
 
 0.516
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.