RPAIN protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

RPAIN

RPA interacting protein. (292 aa)

Predicted Functional Partners:

ETAA1

0.704

ELP5

0.597

KIF6

0.579

METTL16

0.563

RPA1

0.556

SNRPA1

0.521

ENSCAFP00000051873

0.521

TOP3A

0.519

E2RJ84_CANLF

0.515

MIS12

0.515

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E2RJ84_CANLF	KIF6	ENSCAFP00000033569	ENSCAFP00000002258	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.483
E2RJ84_CANLF	RPAIN	ENSCAFP00000033569	ENSCAFP00000047084	Uncharacterized protein.	RPA interacting protein.	0.515
ELP5	METTL16	ENSCAFP00000023743	ENSCAFP00000028485	Elongator acetyltransferase complex subunit 5.	U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...]	0.586
ELP5	RPAIN	ENSCAFP00000023743	ENSCAFP00000047084	Elongator acetyltransferase complex subunit 5.	RPA interacting protein.	0.597
ELP5	TOP3A	ENSCAFP00000023743	ENSCAFP00000026983	Elongator acetyltransferase complex subunit 5.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.535
ENSCAFP00000051873	RPAIN	ENSCAFP00000051873	ENSCAFP00000047084	Uncharacterized protein.	RPA interacting protein.	0.521
ETAA1	RPAIN	ENSCAFP00000004806	ENSCAFP00000047084	ETAA1 activator of ATR kinase.	RPA interacting protein.	0.704
KIF6	E2RJ84_CANLF	ENSCAFP00000002258	ENSCAFP00000033569	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.483
KIF6	MIS12	ENSCAFP00000002258	ENSCAFP00000033588	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.483
KIF6	RPAIN	ENSCAFP00000002258	ENSCAFP00000047084	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	RPA interacting protein.	0.579
METTL16	ELP5	ENSCAFP00000028485	ENSCAFP00000023743	U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...]	Elongator acetyltransferase complex subunit 5.	0.586
METTL16	RPAIN	ENSCAFP00000028485	ENSCAFP00000047084	U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...]	RPA interacting protein.	0.563
METTL16	TOP3A	ENSCAFP00000028485	ENSCAFP00000026983	U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...]	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.515
MIS12	KIF6	ENSCAFP00000033588	ENSCAFP00000002258	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.483
MIS12	RPAIN	ENSCAFP00000033588	ENSCAFP00000047084	Uncharacterized protein.	RPA interacting protein.	0.515
RPA1	RPAIN	ENSCAFP00000028391	ENSCAFP00000047084	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	RPA interacting protein.	0.556
RPA1	TOP3A	ENSCAFP00000028391	ENSCAFP00000026983	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.995
RPAIN	E2RJ84_CANLF	ENSCAFP00000047084	ENSCAFP00000033569	RPA interacting protein.	Uncharacterized protein.	0.515
RPAIN	ELP5	ENSCAFP00000047084	ENSCAFP00000023743	RPA interacting protein.	Elongator acetyltransferase complex subunit 5.	0.597
RPAIN	ENSCAFP00000051873	ENSCAFP00000047084	ENSCAFP00000051873	RPA interacting protein.	Uncharacterized protein.	0.521