ENSCAFP00000047198 protein (Canis lupus familiaris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Databases

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[Homology]

Score

ENSCAFP00000047198

Uncharacterized protein. (99 aa)

Predicted Functional Partners:

LEO1

0.860

POLR2J

0.826

POLR2F

0.822

POLR2E

0.806

POLR1D

0.802

POLR2H

0.802

POLR3H

0.802

POLR3K

0.796

TWISTNB

0.784

ZNRD1

0.783

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAFP00000047198	LEO1	ENSCAFP00000047198	ENSCAFP00000044474	Uncharacterized protein.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.860
ENSCAFP00000047198	POLR1D	ENSCAFP00000047198	ENSCAFP00000010078	Uncharacterized protein.	RNA polymerase I and III subunit D.	0.802
ENSCAFP00000047198	POLR2E	ENSCAFP00000047198	ENSCAFP00000028908	Uncharacterized protein.	RNA polymerase II subunit E.	0.806
ENSCAFP00000047198	POLR2F	ENSCAFP00000047198	ENSCAFP00000054958	Uncharacterized protein.	RNA polymerase II subunit F.	0.822
ENSCAFP00000047198	POLR2H	ENSCAFP00000047198	ENSCAFP00000051294	Uncharacterized protein.	RNA polymerase II subunit H.	0.802
ENSCAFP00000047198	POLR2J	ENSCAFP00000047198	ENSCAFP00000033935	Uncharacterized protein.	RNA polymerase II subunit J.	0.826
ENSCAFP00000047198	POLR3H	ENSCAFP00000047198	ENSCAFP00000056592	Uncharacterized protein.	RNA polymerase III subunit H.	0.802
ENSCAFP00000047198	POLR3K	ENSCAFP00000047198	ENSCAFP00000029178	Uncharacterized protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.796
ENSCAFP00000047198	TWISTNB	ENSCAFP00000047198	ENSCAFP00000003662	Uncharacterized protein.	TWIST neighbor.	0.784
ENSCAFP00000047198	ZNRD1	ENSCAFP00000047198	ENSCAFP00000017950	Uncharacterized protein.	Zinc ribbon domain containing 1.	0.783
LEO1	ENSCAFP00000047198	ENSCAFP00000044474	ENSCAFP00000047198	LEO1 homolog, Paf1/RNA polymerase II complex component.	Uncharacterized protein.	0.860
LEO1	POLR2E	ENSCAFP00000044474	ENSCAFP00000028908	LEO1 homolog, Paf1/RNA polymerase II complex component.	RNA polymerase II subunit E.	0.978
LEO1	POLR2F	ENSCAFP00000044474	ENSCAFP00000054958	LEO1 homolog, Paf1/RNA polymerase II complex component.	RNA polymerase II subunit F.	0.979
LEO1	POLR2H	ENSCAFP00000044474	ENSCAFP00000051294	LEO1 homolog, Paf1/RNA polymerase II complex component.	RNA polymerase II subunit H.	0.978
LEO1	POLR2J	ENSCAFP00000044474	ENSCAFP00000033935	LEO1 homolog, Paf1/RNA polymerase II complex component.	RNA polymerase II subunit J.	0.896
LEO1	POLR3K	ENSCAFP00000044474	ENSCAFP00000029178	LEO1 homolog, Paf1/RNA polymerase II complex component.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.735
LEO1	ZNRD1	ENSCAFP00000044474	ENSCAFP00000017950	LEO1 homolog, Paf1/RNA polymerase II complex component.	Zinc ribbon domain containing 1.	0.729
POLR1D	ENSCAFP00000047198	ENSCAFP00000010078	ENSCAFP00000047198	RNA polymerase I and III subunit D.	Uncharacterized protein.	0.802
POLR1D	POLR2E	ENSCAFP00000010078	ENSCAFP00000028908	RNA polymerase I and III subunit D.	RNA polymerase II subunit E.	0.996
POLR1D	POLR2F	ENSCAFP00000010078	ENSCAFP00000054958	RNA polymerase I and III subunit D.	RNA polymerase II subunit F.	0.991

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.825

expected number of edges:

15

PPI enrichment p-value:

0.00198

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009432

SOS response

4 of 11

1.79

1.5

0.00075

GO:0006260

DNA replication

5 of 38

1.35

1.19

0.00083

GO:0006281

DNA repair

5 of 44

1.29

1.13

0.00083

GO:0006259

DNA metabolic process

7 of 128

0.97

0.83

0.00083

GO:0051301

Cell division

3 of 22

1.37

0.78

0.0179

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015648

Lipid-linked peptidoglycan transporter activity

3 of 4

2.11

1.37

0.0024

GO:0003887

DNA-directed DNA polymerase activity

3 of 8

1.81

1.27

0.0027

GO:0140097

Catalytic activity, acting on DNA

5 of 73

1.07

0.83

0.0027

GO:0003684

Damaged DNA binding

2 of 6

1.76

0.73

0.0388

GO:0004252

Serine-type endopeptidase activity

2 of 8

1.63

0.67

0.0487

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:556

Mixed, incl. DNA replication, and Nucleotide excision repair

4 of 29

1.37

0.88

0.0096

CL:558

Mixed, incl. Nucleotide excision repair, and Mre11 nuclease, N-terminal metallophosphatase domain

3 of 18

1.46

0.75

0.0253

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03420

Nucleotide excision repair

3 of 14

1.56

0.96

0.0091

map03430

Mismatch repair

3 of 27

1.28

0.69

0.0261

map03440

Homologous recombination

3 of 31

1.22

0.67

0.0261

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032153

Cell division site

3 of 5

2.01

1.43

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0235

DNA replication

3 of 14

1.56

0.9

0.0130

KW-0239

DNA-directed DNA polymerase

2 of 5

1.84

0.88

0.0196

KW-0234

DNA repair

3 of 23

1.35

0.77

0.0181

KW-0227

DNA damage

3 of 23

1.35

0.77

0.0181

KW-0742

SOS response

2 of 8

1.63

0.73

0.0346

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01098

Cell cycle protein

3 of 3

2.23

1.62

0.00083

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001182

Probable peptidoglycan glycosyltransferase FtsW/RodA

3 of 3

2.23

1.39

0.0024

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