PTPRB protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PTPRB

Protein tyrosine phosphatase receptor type B. (2259 aa)

Predicted Functional Partners:

CTNNB1

0.924

PTPN1

0.911

CDH5

0.712

TBC1D31

0.708

ADGRF5

0.687

PLCG1

0.632

NOL10

0.566

TEK

0.549

PDE11A

0.526

WDFY2

0.524

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRF5	CDH5	ENSCAFP00000066637	ENSCAFP00000030279	Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family.	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.614
ADGRF5	PTPRB	ENSCAFP00000066637	ENSCAFP00000047413	Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family.	Protein tyrosine phosphatase receptor type B.	0.687
ADGRF5	TEK	ENSCAFP00000066637	ENSCAFP00000047151	Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family.	TEK receptor tyrosine kinase.	0.438
CDH5	ADGRF5	ENSCAFP00000030279	ENSCAFP00000066637	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family.	0.614
CDH5	CTNNB1	ENSCAFP00000030279	ENSCAFP00000007783	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.999
CDH5	PTPRB	ENSCAFP00000030279	ENSCAFP00000047413	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Protein tyrosine phosphatase receptor type B.	0.712
CDH5	TEK	ENSCAFP00000030279	ENSCAFP00000047151	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	TEK receptor tyrosine kinase.	0.691
CTNNB1	CDH5	ENSCAFP00000007783	ENSCAFP00000030279	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.999
CTNNB1	PTPN1	ENSCAFP00000007783	ENSCAFP00000035390	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Tyrosine-protein phosphatase non-receptor type.	0.922
CTNNB1	PTPRB	ENSCAFP00000007783	ENSCAFP00000047413	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Protein tyrosine phosphatase receptor type B.	0.924
CTNNB1	TEK	ENSCAFP00000007783	ENSCAFP00000047151	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	TEK receptor tyrosine kinase.	0.417
NOL10	PTPRB	ENSCAFP00000064542	ENSCAFP00000047413	Nucleolar protein 10.	Protein tyrosine phosphatase receptor type B.	0.566
NOL10	TBC1D31	ENSCAFP00000064542	ENSCAFP00000001400	Nucleolar protein 10.	TBC1 domain family member 31.	0.800
NOL10	WDFY2	ENSCAFP00000064542	ENSCAFP00000006361	Nucleolar protein 10.	WD repeat and FYVE domain containing 2.	0.699
PDE11A	PTPRB	ENSCAFP00000042859	ENSCAFP00000047413	Phosphodiesterase.	Protein tyrosine phosphatase receptor type B.	0.526
PLCG1	PTPRB	ENSCAFP00000046841	ENSCAFP00000047413	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Protein tyrosine phosphatase receptor type B.	0.632
PLCG1	TBC1D31	ENSCAFP00000046841	ENSCAFP00000001400	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	TBC1 domain family member 31.	0.407
PTPN1	CTNNB1	ENSCAFP00000035390	ENSCAFP00000007783	Tyrosine-protein phosphatase non-receptor type.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.922
PTPN1	PTPRB	ENSCAFP00000035390	ENSCAFP00000047413	Tyrosine-protein phosphatase non-receptor type.	Protein tyrosine phosphatase receptor type B.	0.911
PTPRB	ADGRF5	ENSCAFP00000047413	ENSCAFP00000066637	Protein tyrosine phosphatase receptor type B.	Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family.	0.687