STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNP2Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. (130 aa)    
Predicted Functional Partners:
PRM2
Protamine 2.
 
 
  
 0.946
TNP1
Transition protein 1.
   
  
 0.940
NUPR2
Nuclear protein 2, transcriptional regulator.
      
 0.875
MSH4
MutS homolog 4.
   
  
 0.722
PINLYP
Phospholipase A2 inhibitor and LY6/PLAUR domain containing.
   
  
 0.696
GPR149
G protein-coupled receptor 149.
   
  
 0.671
DMRT1
Doublesex and mab-3 related transcription factor 1.
   
  
 0.646
AKAP4
A-kinase anchoring protein 4.
   
  
 0.635
SYCP1
Synaptonemal complex protein 1.
   
 
 0.607
ELOB
Elongin B.
    
 
 0.593
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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