STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDARADDEDAR associated death domain. (216 aa)    
Predicted Functional Partners:
EDAR
Ectodysplasin A receptor.
    
 0.965
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.955
WNT10A
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.
   
  
 0.796
EDA
Ectodysplasin A isoform EDA-A2; Belongs to the tumor necrosis factor family.
     
 0.780
AWAT2
Acyl-CoA wax alcohol acyltransferase 2.
   
  
 0.685
SMIM23
Small integral membrane protein 23.
      
 0.651
PUM1
Pumilio RNA binding family member 1.
   
 
 0.610
PUM2
Pumilio RNA binding family member 2.
   
 
 0.610
BPIFA1
BPI fold containing family A member 1.
   
 
 0.606
CNOT1
CCR4-NOT transcription complex subunit 1.
    
 
 0.586
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.