STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC612025Uncharacterized protein. (295 aa)    
Predicted Functional Partners:
GZMA
Granzyme A; Belongs to the peptidase S1 family.
   
  
 0.897
PRF1
Perforin 1.
   
  
 0.875
CNPY2
Saposin B-type domain-containing protein.
      
 0.723
KLRD1
Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
   
  
 0.695
CTSW
Cathepsin W; Belongs to the peptidase C1 family.
   
  
 0.622
MASP2
Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family.
   
  
 0.609
FASLG
Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family.
   
  
 0.605
GALC
Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity); Belongs to the glycosyl hydrolase 59 family.
    
 
 0.587
IL2RB
Fibronectin type-III domain-containing protein.
   
  
 0.577
PSAP
Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
      
 0.569
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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