LIFR protein (Canis lupus familiaris) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

LIFR

Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity). (1157 aa)

Predicted Functional Partners:

LIF

0.991

OSM

0.984

CTF1

0.975

CNTFR

0.971

JAK1

0.958

JAK2

0.951

IL6ST

0.939

LOC489915

0.926

JAK3

0.916

PIK3R3

0.905

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNTFR	CTF1	ENSCAFP00000002838	ENSCAFP00000024588	Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).	Uncharacterized protein.	0.859
CNTFR	IL6ST	ENSCAFP00000002838	ENSCAFP00000062759	Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).	Uncharacterized protein.	0.873
CNTFR	JAK1	ENSCAFP00000002838	ENSCAFP00000039978	Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).	Tyrosine-protein kinase.	0.679
CNTFR	JAK2	ENSCAFP00000002838	ENSCAFP00000044346	Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).	Janus kinase 2.	0.711
CNTFR	JAK3	ENSCAFP00000002838	ENSCAFP00000041505	Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).	Tyrosine-protein kinase.	0.682
CNTFR	LIF	ENSCAFP00000002838	ENSCAFP00000036140	Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).	LIF interleukin 6 family cytokine.	0.810
CNTFR	LIFR	ENSCAFP00000002838	ENSCAFP00000047973	Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).	Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity).	0.971
CNTFR	LOC489915	ENSCAFP00000002838	ENSCAFP00000055558	Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).	Uncharacterized protein.	0.754
CNTFR	OSM	ENSCAFP00000002838	ENSCAFP00000018361	Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).	Oncostatin M.	0.792
CTF1	CNTFR	ENSCAFP00000024588	ENSCAFP00000002838	Uncharacterized protein.	Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).	0.859
CTF1	IL6ST	ENSCAFP00000024588	ENSCAFP00000062759	Uncharacterized protein.	Uncharacterized protein.	0.913
CTF1	JAK1	ENSCAFP00000024588	ENSCAFP00000039978	Uncharacterized protein.	Tyrosine-protein kinase.	0.629
CTF1	JAK2	ENSCAFP00000024588	ENSCAFP00000044346	Uncharacterized protein.	Janus kinase 2.	0.644
CTF1	LIF	ENSCAFP00000024588	ENSCAFP00000036140	Uncharacterized protein.	LIF interleukin 6 family cytokine.	0.859
CTF1	LIFR	ENSCAFP00000024588	ENSCAFP00000047973	Uncharacterized protein.	Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (By similarity).	0.975
CTF1	LOC489915	ENSCAFP00000024588	ENSCAFP00000055558	Uncharacterized protein.	Uncharacterized protein.	0.902
CTF1	OSM	ENSCAFP00000024588	ENSCAFP00000018361	Uncharacterized protein.	Oncostatin M.	0.943
IL6ST	CNTFR	ENSCAFP00000062759	ENSCAFP00000002838	Uncharacterized protein.	Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity).	0.873
IL6ST	CTF1	ENSCAFP00000062759	ENSCAFP00000024588	Uncharacterized protein.	Uncharacterized protein.	0.913
IL6ST	JAK1	ENSCAFP00000062759	ENSCAFP00000039978	Uncharacterized protein.	Tyrosine-protein kinase.	0.949

page 1 of 5

Network Stats

number of nodes:

10

number of edges:

38

average node degree:

7.6

avg. local clustering coefficient:

0.903

expected number of edges:

10

PPI enrichment p-value:

2.79e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031463

Cul3-RING ubiquitin ligase complex

4 of 40

2.26

2.57

9.83e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37495603

(2023) A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.

3 of 26

2.33

0.87

0.0251

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:27170

Mostly uncharacterized, incl. Cerebellum maturation, and Telomeric loop formation

3 of 18

2.49

1.7

0.00072

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-8951664

Neddylation

5 of 214

1.63

1.71

0.00010

CFA-983168

Antigen processing: Ubiquitination & Proteasome degradation

4 of 280

1.42

0.95

0.0067

CFA-597592

Post-translational protein modification

6 of 1073

1.01

0.72

0.0067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031463

Cul3-RING ubiquitin ligase complex

3 of 31

2.25

1.53

0.0013

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0880

Kelch repeat

3 of 48

2.06

1.54

0.0010

KW-0677

Repeat

5 of 1186

0.89

0.47

0.0497

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00875

BTB And C-terminal Kelch

3 of 56

1.99

1.29

0.0031

SM00225

Broad-Complex, Tramtrack and Bric a brac

3 of 158

1.54

0.73

0.0316

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